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CANNABIS SATIVA (HEMP) FLOWER/LEAF/STEM EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Neurotoxicity (low), Endocrine disruption (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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facial moisturizer/treatment3 products
moisturizer1 products
anti-aging1 products
bath oil/salts/soak1 products
serums & essences1 products
muscle/joint soreness1 products

Use restrictions

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Concern Reference
Prohibited in European cosmetics: must not form part of the composition of cosmetic productsEU Cosmetics Directive 2019. CosIng. Appears as: listid: COSING-91197; Chemical_Name: CANNABIDIOL - DERIVED FROM EXTRACT OR TINCTURE OR RESIN OF CANNABIS; Synonyms: 1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; CAS: 13956-29-1

Organ system toxicity (non-reproductive)

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Concern Reference
Cannabis extract high in cannabidiol induced liver toxicity in mice.Laura E Ewing, Charles M. Skinner, Charles M. Quick, Stefanie Kennon-McGill, Mitchell R. McGill, Larry A. Walker, Mahmoud A. ElSohly, Bill J. Gurley & Igor Koturbash. 2019. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules (Basel, Switzerland) 24(9).
CLP notifications this substance may be fatal if swallowed and enters airways.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: CANNABIS SATIVA FLOWER/LEAF/STEM EXTRACT; CANNABIS SATIVA (HEMP) EXTRACT; CANNABIS SATIVA (HEMP) SEED OIL; cas_numbers: 89958-21-4

Developmental/reproductive toxicity

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Concern Reference
Cannabis extract (evidently high in THC) induced testicular toxicity in mice.Tapas K Mandal & Nildari S. Das. 2010. Testicular toxicity in cannabis extract treated mice: association with oxidative stress and role of antioxidant enzyme systems. Toxicology and industrial health 26(1), 11-23.

Endocrine disruption

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Concern Reference
Cannabis extract exhibited antiestrogenic effects in rats.I Charavarty, D. Sengupta, P. Bhattacharyya & J. Ghosh. 1975. Effect of treatment with cannabis extract on the water and glycogen contents of the uterus in normal and estradiol-treated prepubertal rats. Toxicology and applied pharmacology 34(3), 513-6.
Cannabis extracts, including both THC and CBD, exhibited endocrine disrupting effects in vitro.Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono & Ikuo Yamamoto 2005. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology 206(3), 471-8.

Allergies/immunotoxicity

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Concern Reference
CLP notifications this substance may cause an allergic skin reaction.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: CANNABIS SATIVA FLOWER/LEAF/STEM EXTRACT; CANNABIS SATIVA (HEMP) EXTRACT; CANNABIS SATIVA (HEMP) SEED OIL; cas_numbers: 89958-21-4

Irritation (skin, eyes, or lungs)

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Concern Reference
Cannabis extract and THC, but not CBD, induced ocular toxicity (irritation) in cats.B K. Colasanti, R. E. Brown & C. R. Craig. 1984. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. General pharmacology 15(6), 479-84.
CLP notifications this substance causes serious eye irritationEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: CANNABIS SATIVA FLOWER/LEAF/STEM EXTRACT; CANNABIS SATIVA (HEMP) EXTRACT; CANNABIS SATIVA (HEMP) SEED OIL; cas_numbers: 89958-21-4

Neurotoxicity

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Concern Reference
Cannabis extract containing tetrahydrocannabidiol induced neurotoxic effects in mice. (Omar M E. Abdel-Salam, Neveen A. Salem, Marwa El-Sayed El-Shamarka, Noha Al-Said Ahmed, Jihan Seid Hussein & Zakaria A. El-Khyat. 2013. Cannabis-induced impairment of learning and memory: effect of different nootropic drugs. EXCLI journal 12, 193-214.

Ecotoxicology

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Concern Reference
CLP notifications this substance is toxic to aquatic life with long lasting effects.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: CANNABIS SATIVA FLOWER/LEAF/STEM EXTRACT; CANNABIS SATIVA (HEMP) EXTRACT; CANNABIS SATIVA (HEMP) SEED OIL; cas_numbers: 89958-21-4

Data Sources

  • EU Cosmetics Directive 2019. CosIng. Appears as: listid: COSING-91197; Chemical_Name: CANNABIDIOL - DERIVED FROM EXTRACT OR TINCTURE OR RESIN OF CANNABIS; Synonyms: 1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; CAS: 13956-29-1
  • Laura E Ewing, Charles M. Skinner, Charles M. Quick, Stefanie Kennon-McGill, Mitchell R. McGill, Larry A. Walker, Mahmoud A. ElSohly, Bill J. Gurley & Igor Koturbash. 2019. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules (Basel, Switzerland) 24(9).
  • European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: CANNABIS SATIVA FLOWER/LEAF/STEM EXTRACT; CANNABIS SATIVA (HEMP) EXTRACT; CANNABIS SATIVA (HEMP) SEED OIL; cas_numbers: 89958-21-4
  • Tapas K Mandal & Nildari S. Das. 2010. Testicular toxicity in cannabis extract treated mice: association with oxidative stress and role of antioxidant enzyme systems. Toxicology and industrial health 26(1), 11-23.
  • I Charavarty, D. Sengupta, P. Bhattacharyya & J. Ghosh. 1975. Effect of treatment with cannabis extract on the water and glycogen contents of the uterus in normal and estradiol-treated prepubertal rats. Toxicology and applied pharmacology 34(3), 513-6.
  • Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono & Ikuo Yamamoto 2005. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology 206(3), 471-8.
  • B K. Colasanti, R. E. Brown & C. R. Craig. 1984. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. General pharmacology 15(6), 479-84.
  • Omar M E. Abdel-Salam, Neveen A. Salem, Marwa El-Sayed El-Shamarka, Noha Al-Said Ahmed, Jihan Seid Hussein & Zakaria A. El-Khyat. 2013. Cannabis-induced impairment of learning and memory: effect of different nootropic drugs. EXCLI journal 12, 193-214.

About this Ingredient's Score Range

  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

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