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CITRUS AURANTIFOLIA (LIME) PEEL OIL

Score:

Data: None

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Persistence and bioaccumulation (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (high)

Cancer

Cancer concern is LOW_MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial moisturizer/treatment7 products
beach & sport sunscreen3 products
facial cleanser3 products
body wash/cleanser2 products
anti-aging2 products
hand cream1 products
shampoo1 products
conditioner1 products
antiperspirant/deodorant1 products
muscle/joint soreness1 products
after sun product1 products
liquid hand soap1 products
makeup primer1 products
serums & essences1 products
toners/astringents1 products
shaving cream1 products
hair treatment/serum1 products
mask1 products
makeup remover1 products

Allergies/immunotoxicity

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Concern Reference
Known human skin toxicant or allergenEU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011)
Fragrance chemical, which is less frequently reported and thus less documented as a consumer allergen.European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
Human [[system]] toxicant or allergen - strong evidenceEnvironmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
May cause sensitization by skin contactEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
May cause sensitization by skin contact, with allergic reaction in skin or lungsUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5

Irritation (skin, eyes, or lungs)

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Concern Reference
Irritating to skinEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Restrictions recommended due to presence of photoirritating components.International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative toxicant - Limited or emerging evidence in open scientific literaturePeer Reviewed Literature 2015. Emerging PBTs from peer-reviewed literature. Appears as: listid: PBT-PEER-038; Chemical_Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; ; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5

Use restrictions

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Concern Reference
Fragrance subject to restrictions: safe only within recommended use or concentration limitsInternational Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-087; Chemical_Name: Lime oil expressed; ; CAS: 8008-26-2; Classification: Restricted
Restricted in cosmetics - labeling requirement for allergensEU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5

Cancer

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Concern Reference
Restrictions recommended due to presence of phototumorigenic components.International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted
IARC Group 3 (no cancer link)IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5

Developmental/reproductive toxicity

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Concern Reference
Developmental toxicity (significant increase in the number of fetuses with skeletal abnormalities, including lumbar ribs, fused ribs, and delayed ossification of several bones in the paws) were observed in the animals administered 2363 mg/kg/day.1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.

Ecotoxicology

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Concern Reference
Dangerous for the environmentEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-07010; Chemical_Name: Oils, lime; ; CAS: 8008-26-2

Miscellaneous

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Concern Reference
FlammableEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5

Multiple, additive exposure sources

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Concern Reference
Fully up-to-date toxicology information has been sought.US. Food and Drug Administration (FDA). 2015. Everything Added to Food. Appears as: listid: EAFUS-2301; Chemical_Name: LIME OIL, DISTILLED; ; CAS: 8008-26-2

Organ system toxicity (non-reproductive)

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Concern Reference
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5

Data Sources

  • EU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011)
  • European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
  • Environmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
  • EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
  • US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted
  • Peer Reviewed Literature 2015. Emerging PBTs from peer-reviewed literature. Appears as: listid: PBT-PEER-038; Chemical_Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; ; CAS: 5989-27-5
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
  • International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-087; Chemical_Name: Lime oil expressed; ; CAS: 8008-26-2; Classification: Restricted
  • EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5
  • IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-07010; Chemical_Name: Oils, lime; ; CAS: 8008-26-2
  • US. Food and Drug Administration (FDA). 2015. Everything Added to Food. Appears as: listid: EAFUS-2301; Chemical_Name: LIME OIL, DISTILLED; ; CAS: 8008-26-2

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer