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Citrus Aurantium Dulcis (Orange) Peel Oil
Score:
Data: None
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| facial moisturizer/treatment | 80 products |
| body wash/cleanser | 64 products |
| moisturizer | 61 products |
| shampoo | 60 products |
| liquid hand soap | 45 products |
| moisturizer with SPF | 45 products |
| serums & essences | 44 products |
| facial cleanser | 37 products |
| conditioner | 37 products |
| mask | 33 products |
| beach & sport sunscreen | 30 products |
| exfoliant/scrub | 25 products |
| antiperspirant/deodorant | 22 products |
| foundation | 19 products |
| lip balm | 19 products |
| hair treatment/serum | 17 products |
| CC cream | 15 products |
| bath oil/salts/soak | 13 products |
| hand sanitizer | 13 products |
| body oil | 10 products |
| bubble bath | 10 products |
| hair styling aide | 9 products |
| toners/astringents | 8 products |
| makeup remover | 8 products |
| body firming lotion | 7 products |
| shaving cream (men's) | 7 products |
| styling gel/lotion | 7 products |
| bar soap | 7 products |
| anti-aging | 7 products |
| hand cream | 6 products |
| baby shampoo | 6 products |
| after sun product | 5 products |
| baby soap | 5 products |
| hair spray | 5 products |
| lipstick | 5 products |
| makeup primer | 5 products |
| around-eye cream | 4 products |
| BB cream | 4 products |
| fragrance for women | 3 products |
| detangler | 3 products |
| after shave | 3 products |
| blush | 3 products |
| antiperspirant/deodorant (men's) | 3 products |
| shaving cream | 3 products |
| sunless tanning | 2 products |
| body spray | 2 products |
| toothpaste | 2 products |
| baby sunscreen | 2 products |
| lip plumper | 1 products |
| baby wipes | 1 products |
| eye liner | 1 products |
| vapor rubs | 1 products |
| eye makeup remover | 1 products |
| lip balm with SPF | 1 products |
| beard oil | 1 products |
| 1 products | |
| brow liner | 1 products |
| styling mousse/foam | 1 products |
| baby bubble bath | 1 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Known human dermal toxicant or allergen | Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive |
| Fragrance chemical, which is less frequently reported and thus less documented as a consumer allergen. | European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene; |
| Human [[system]] toxicant or allergen - strong evidence | Environmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)- |
| May cause sensitization by skin contact | EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5 |
| May cause sensitization by skin contact, with allergic reaction in skin or lungs | US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5 |
| REACH registrations this substance may cause an allergic skin reaction. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3 |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Irritating to skin | EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5 |
| Restrictions recommended due to presence of photoirritating components. | International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted |
| REACH registrations this substance causes skin irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3 |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Persistent, bioaccumulative toxicant - Limited or emerging evidence in open scientific literature | Peer Reviewed Literature 2015. Emerging PBTs from peer-reviewed literature. Appears as: listid: PBT-PEER-038; Chemical_Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; ; CAS: 5989-27-5 |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5 |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Deemed a moderate human health priority and was flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-07018; Chemical_Name: Oils, orange, sweet; ; CAS: 8008-57-9 |
| Deemed a moderate human health priority and was flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-07018; Chemical_Name: Oils, orange, sweet; ; CAS: 8008-57-9 |
| REACH registrations this substance may be fatal if swallowed and enters airways. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3 |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5 |
Cancer
| Concern | Reference |
|---|---|
| Restrictions recommended due to presence of phototumorigenic components. | International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted |
| IARC Group 3 (no cancer link) | IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5 |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| Developmental toxicity (significant increase in the number of fetuses with skeletal abnormalities, including lumbar ribs, fused ribs, and delayed ossification of several bones in the paws) were observed in the animals administered 2363 mg/kg/day. | 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Dangerous for the environment | EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5 |
| Deemed a moderate human health priority and was flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-07018; Chemical_Name: Oils, orange, sweet; ; CAS: 8008-57-9 |
| REACH registrations this substance is toxic to aquatic life with long lasting effects. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3 |
Data gaps
| Concern | Reference |
|---|---|
| Insufficient data to support safe use in cosmetics | Cosmetic Ingredient Review (CIR) 2017. CIR Assessments. Appears as: ; Chemical_Name: Citrus Aurantium Dulcis (Orange) Oil; ; ; Classification: QQQ03; |
Miscellaneous
| Concern | Reference |
|---|---|
| Flammable | EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5 |
Multiple, additive exposure sources
| Concern | Reference |
|---|---|
| Fully up-to-date toxicology information has been sought. | US. Food and Drug Administration (FDA). 2015. Everything Added to Food. Appears as: listid: EAFUS-2489; Chemical_Name: ORANGE PEEL, SWEET, OIL (CITRUS SINENSIS (L.) OSBECK); ; CAS: 8008-57-9 |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics - labeling requirement for allergens | EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5 |
Data Sources
- Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
- European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
- Environmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
- EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
- US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3
- International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted
- Peer Reviewed Literature 2015. Emerging PBTs from peer-reviewed literature. Appears as: listid: PBT-PEER-038; Chemical_Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; ; CAS: 5989-27-5
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-07018; Chemical_Name: Oils, orange, sweet; ; CAS: 8008-57-9
- IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
- 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.
- Cosmetic Ingredient Review (CIR) 2017. CIR Assessments. Appears as: ; Chemical_Name: Citrus Aurantium Dulcis (Orange) Oil; ; ; Classification: QQQ03;
- US. Food and Drug Administration (FDA). 2015. Everything Added to Food. Appears as: listid: EAFUS-2489; Chemical_Name: ORANGE PEEL, SWEET, OIL (CITRUS SINENSIS (L.) OSBECK); ; CAS: 8008-57-9
- EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5
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