Menu Close Menu

Menu

CANNABIDIOL (CBD)

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Neurotoxicity (low), Endocrine disruption (low), and Non-reproductive organ system toxicity (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

Expand content Collapse content
facial moisturizer/treatment1 products
serums & essences1 products

Use restrictions

Expand content Collapse content
Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Cannabis extract high in cannabidiol induced liver toxicity in mice.Laura E Ewing, Charles M. Skinner, Charles M. Quick, Stefanie Kennon-McGill, Mitchell R. McGill, Larry A. Walker, Mahmoud A. ElSohly, Bill J. Gurley & Igor Koturbash. 2019. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules (Basel, Switzerland) 24(9).

Neurotoxicity

Expand content Collapse content
Concern Reference
One or more in vitro tests on mammalian cells demonstrate neurotoxicityPatrícia Schönhofen, Richard B Parsons, Mauro Antônio A. Castro, José Alexandre S. Crippa, Flávio Kapczinski, Marco A. De Bastiani, Fernanda M. Lopes, Ivi Juliana Bristot, Liana M. de Medeiros & Fábio Klamt. 2015. Cannabidiol Exposure During Neuronal Differentiation Sensitizes Cells Against Redox-Active Neurotoxins. Molecular neurobiology 52(1), 26-37.

Developmental/reproductive toxicity

Expand content Collapse content
Concern Reference
One or more animal studies show reproductive effects at high doses2018 Chronic exposure to cannabidiol induces reproductive toxicity in male Swiss mice.

Endocrine disruption

Expand content Collapse content
Concern Reference
One or more animal studies show any disruption at high doses2018 Chronic cannabidiol exposure promotes functional impairment in sexual behavior and fertility of male mice.
Cannabis extracts, including both THC and CBD, exhibited endocrine disrupting effects in vitro.Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono & Ikuo Yamamoto 2005. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology 206(3), 471-8.

Data Sources

  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Laura E Ewing, Charles M. Skinner, Charles M. Quick, Stefanie Kennon-McGill, Mitchell R. McGill, Larry A. Walker, Mahmoud A. ElSohly, Bill J. Gurley & Igor Koturbash. 2019. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules (Basel, Switzerland) 24(9).
  • Patrícia Schönhofen, Richard B Parsons, Mauro Antônio A. Castro, José Alexandre S. Crippa, Flávio Kapczinski, Marco A. De Bastiani, Fernanda M. Lopes, Ivi Juliana Bristot, Liana M. de Medeiros & Fábio Klamt. 2015. Cannabidiol Exposure During Neuronal Differentiation Sensitizes Cells Against Redox-Active Neurotoxins. Molecular neurobiology 52(1), 26-37.
  • 2018 Chronic exposure to cannabidiol induces reproductive toxicity in male Swiss mice.
  • 2018 Chronic cannabidiol exposure promotes functional impairment in sexual behavior and fertility of male mice.
  • Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono & Ikuo Yamamoto 2005. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology 206(3), 471-8.

About this Ingredient's Score Range

  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer