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AZADIRACHTA INDICA LEAF EXTRACT
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Endocrine disruption (low) and Ecotoxicology (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| facial moisturizer/treatment | 20 products |
| mask | 17 products |
| shampoo | 15 products |
| serums & essences | 14 products |
| facial cleanser | 10 products |
| conditioner | 7 products |
| moisturizer | 7 products |
| toothpaste | 7 products |
| toners/astringents | 6 products |
| body wash/cleanser | 4 products |
| makeup remover | 4 products |
| exfoliant/scrub | 4 products |
| body oil | 3 products |
| lip gloss | 3 products |
| around-eye cream | 2 products |
| beach & sport sunscreen | 2 products |
| anti-aging | 2 products |
| hair treatment/serum | 2 products |
| makeup primer | 2 products |
| bar soap | 1 products |
| lip balm | 1 products |
| eye makeup remover | 1 products |
| hand cream | 1 products |
| tanning oil | 1 products |
| bath oil/salts/soak | 1 products |
| antiperspirant/deodorant | 1 products |
| foot cleansing | 1 products |
| styling gel/lotion | 1 products |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| A review article reports this substance is used in traditional medicine as an anti-fertility drug, with evidence of efficacy from animal studies. Thus, it can be considered a reproductive toxin. | Shail K Chaube, Tulsidas G. Shrivastav, Meenakshi Tiwari, Shilpa Prasad, Anima Tripathi & Ajai K. Pandey. 2014. Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals. SpringerPlus 3, 464. |
Cancer
| Concern | Reference |
|---|---|
| A peer-reviewed study found that this substance was genotoxic to sperm in mice. | K S. Awasthy. 2001. Genotoxicity of a crude leaf extract of neem in male germ cells of mice. Cytobios 106 Suppl 2, 151-64. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Harmonized classification: harmful to aquatic life with long lasting effects. | EU GHS Hazard Labeling Codes 2020. GHS Hazard Codes. Appears as: Chemical Name: Margosa, ext.; CAS number: 84696-25-3; Classification Hazard Statement Codes: H412 |
Endocrine disruption
| Concern | Reference |
|---|---|
| A peer-reviewed study found this substance disrupts thyroid hormone physiology in mice. | S Panda & A. Kar. 2000. How safe is neem extract with respect to thyroid function in male mice?. Pharmacological research 41(4), 419-22. |
Data Sources
- Shail K Chaube, Tulsidas G. Shrivastav, Meenakshi Tiwari, Shilpa Prasad, Anima Tripathi & Ajai K. Pandey. 2014. Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals. SpringerPlus 3, 464.
- K S. Awasthy. 2001. Genotoxicity of a crude leaf extract of neem in male germ cells of mice. Cytobios 106 Suppl 2, 151-64.
- EU GHS Hazard Labeling Codes 2020. GHS Hazard Codes. Appears as: Chemical Name: Margosa, ext.; CAS number: 84696-25-3; Classification Hazard Statement Codes: H412
- S Panda & A. Kar. 2000. How safe is neem extract with respect to thyroid function in male mice?. Pharmacological research 41(4), 419-22.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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