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AZADIRACHTA INDICA LEAF EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Endocrine disruption (low) and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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facial moisturizer/treatment26 products
mask24 products
serums & essences24 products
facial cleanser15 products
shampoo13 products
toners/astringents12 products
conditioner11 products
moisturizer10 products
toothpaste9 products
exfoliant/scrub8 products
around-eye cream4 products
lip gloss4 products
makeup remover4 products
body wash/cleanser4 products
setting powder/spray3 products
makeup primer2 products
hair treatment/serum2 products
recreational sunscreen2 products
anti-aging2 products
antiperspirant/deodorant1 products
styling gel/lotion1 products
hand cream1 products
foot cleansing1 products
eye makeup remover1 products
liquid hand soap1 products
mouthwash1 products
shaving cream1 products
tanning oil1 products
bar soap1 products
body spray1 products
tooth whitening1 products
body oil1 products
bronzer/highlighter1 products
lip balm1 products

Developmental/reproductive toxicity

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Concern Reference
A review article reports this substance is used in traditional medicine as an anti-fertility drug, with evidence of efficacy from animal studies. Thus, it can be considered a reproductive toxin.Shail K Chaube, Tulsidas G. Shrivastav, Meenakshi Tiwari, Shilpa Prasad, Anima Tripathi & Ajai K. Pandey. 2014. Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals. SpringerPlus 3, 464.

Cancer

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Concern Reference
A peer-reviewed study found that this substance was genotoxic to sperm in mice.K S. Awasthy. 2001. Genotoxicity of a crude leaf extract of neem in male germ cells of mice. Cytobios 106 Suppl 2, 151-64.

Ecotoxicology

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Concern Reference
Harmonized classification: harmful to aquatic life with long lasting effects. EU GHS Hazard Labeling Codes 2020. GHS Hazard Codes. Appears as: Chemical Name: Margosa, ext.; CAS number: 84696-25-3; Classification Hazard Statement Codes: H412

Endocrine disruption

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Concern Reference
A peer-reviewed study found this substance disrupts thyroid hormone physiology in mice.S Panda & A. Kar. 2000. How safe is neem extract with respect to thyroid function in male mice?. Pharmacological research 41(4), 419-22.

Data Sources

  • Shail K Chaube, Tulsidas G. Shrivastav, Meenakshi Tiwari, Shilpa Prasad, Anima Tripathi & Ajai K. Pandey. 2014. Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals. SpringerPlus 3, 464.
  • K S. Awasthy. 2001. Genotoxicity of a crude leaf extract of neem in male germ cells of mice. Cytobios 106 Suppl 2, 151-64.
  • EU GHS Hazard Labeling Codes 2020. GHS Hazard Codes. Appears as: Chemical Name: Margosa, ext.; CAS number: 84696-25-3; Classification Hazard Statement Codes: H412
  • S Panda & A. Kar. 2000. How safe is neem extract with respect to thyroid function in male mice?. Pharmacological research 41(4), 419-22.

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