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ISOOCTADECANOIC ACID

Score:

Data: Limited

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick21 products
foundation18 products
lip gloss10 products
bronzer/highlighter8 products
moisturizer with SPF4 products
makeup primer3 products
mascara3 products
makeup remover1 products
lip balm1 products
brow liner1 products
BB cream1 products
serums & essences1 products
facial cleanser1 products

Enhanced skin absorption

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Concern Reference
Isostearic acid is a penetration enhancer.B J. Aungst. 1989. Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants. Pharmaceutical research 6(3), 244-7.

Endocrine disruption

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Concern Reference
Cellular assays found evidence of weak endocrine disruption.National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 30399-84-9; Chemical_Name: Isooctadecanoic acid

Allergies/immunotoxicity

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Concern Reference
Safe for use when formulated to be non-sensitizingCosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0542; Chemical_Name: ISOSTEARIC ACID; ; ; Classification: QQQ01,QQQ10,QQQ11,QQQ53,QQQ54;

Irritation (skin, eyes, or lungs)

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Concern Reference
Safe for use when formulated to be non-irritatingCosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0542; Chemical_Name: ISOSTEARIC ACID; ; ; Classification: QQQ01,QQQ10,QQQ11,QQQ53,QQQ54;

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Industry safety panel (Cosmetic Ingredient Review, CIR) notes missing safety data in its review of this ingredientCosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0542; Chemical_Name: ISOSTEARIC ACID; ; ; Classification: QQQ01,QQQ10,QQQ11,QQQ53,QQQ54;

Informational

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Concern Reference
Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR)Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0542; Chemical_Name: ISOSTEARIC ACID; ; ; Classification: QQQ01,QQQ10,QQQ11,QQQ53,QQQ54;

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • B J. Aungst. 1989. Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants. Pharmaceutical research 6(3), 244-7.
  • National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 30399-84-9; Chemical_Name: Isooctadecanoic acid
  • Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0542; Chemical_Name: ISOSTEARIC ACID; ; ; Classification: QQQ01,QQQ10,QQQ11,QQQ53,QQQ54;
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.

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