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P-TOLUIDINE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Classified as irritant | CPS&Q - Classification & Labelling |
| Limited evidence of skin irritation | National Library of Medicine HazMap |
Occupational hazards
| Concern | Reference |
|---|---|
| Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as a high human health priority | Environment Canada Domestic Substance List |
| Classified as toxic or harmful | CPS&Q - Classification & Labelling |
| Limited evidence of cardiovascular or blood toxicity | National Library of Medicine HazMap |
| Limited evidence of cardiovascular or blood toxicity | A Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, LaDou, J. (ed.). Occupational Medicine. Appleton & Lange, Norwalk, CN. 1990. |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Cancer
| Concern | Reference |
|---|---|
| Limited evidence of carcinogenicity | CPS&Q - Classification & Labelling |
| Limited evidence of carcinogenicity | Amer Conf of Gov't Industrial Hygienists - Carcinogens |
| Limited evidence of carcinogenicity | NIOSH Occupational Carcinogens |
| Cancer - limited evidence | US EPA, Office of Emergency Response and Remediation Superfund Chemical Data Matrix. http://www.epa.gov/superfund/resources/scdm/index.htm |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Limited evidence of immune system toxicity or allergies | CPS&Q - Classification & Labelling |
Ecotoxicology
| Concern | Reference |
|---|---|
| Wildlife and environmental toxicity | CPS&Q - Classification & Labelling |
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| 376 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- A Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, LaDou, J. (ed.). Occupational Medicine. Appleton & Lange, Norwalk, CN. 1990.
- ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
- NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
- US EPA, Office of Emergency Response and Remediation Superfund Chemical Data Matrix. http://www.epa.gov/superfund/resources/scdm/index.htm
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
- This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
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