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Data: Robust

4 O Tolylazo O Toluidine

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Non-reproductive organ system toxicity (moderate)

SYNONYMS

● 4-O-TOLYLAZO-O-TOLUIDINE

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


Common concerns

See how this product scores for common concerns.

  • MODERATE
    Cancer
  • MODERATE
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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bar soap4 products
around-eye cream3 products
moisturizer3 products
mask2 products
bath oil/salts/soak2 products
body wash/cleanser2 products
shampoo1 products
facial cleanser1 products
liquid hand soap1 products
hair-loss treatment1 products
shaving cream1 products
exfoliant/scrub1 products
baby lotion1 products
daily use with SPF1 products
baby shampoo1 products

Cancer

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CONCERN REFERENCE
Possible human carcinogenCPS&Q - Classification & Labelling
Possible human carcinogenCalifornia EPA Proposition 65
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Cancer - strong evidenceScorecard.org Toxicity Information
Limited evidence of carcinogenicityInt'l Agency for Research on Cancer (IARC) - Carcinogens
Cancer - limited evidenceSilent Spring's Mammary Carcinogens Reviews Database

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as a high human health priorityEnvironment Canada Domestic Substance List
Limited evidence of sense organ toxicityScorecard.org Toxicity Information
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Allergies/immunotoxicity

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CONCERN REFERENCE
Limited evidence of immune system toxicity or allergiesCPS&Q - Classification & Labelling
Limited evidence of immune system toxicity or allergiesScorecard.org Toxicity Information

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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CONCERN REFERENCE
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

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CONCERN REFERENCE
3238 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
  • NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
  • Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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