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CITRUS RETICULATA OIL
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (low), Persistence and bioaccumulation (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| moisturizer | 27 products |
| body wash/cleanser | 19 products |
| foundation | 17 products |
| exfoliant/scrub | 15 products |
| bath oil/salts/soak | 14 products |
| lip balm | 13 products |
| daily use with SPF | 13 products |
| shampoo | 12 products |
| liquid hand soap | 12 products |
| body spray | 10 products |
| body oil | 8 products |
| bar soap | 8 products |
| hair treatment/serum | 7 products |
| CC cream | 7 products |
| antiperspirant/deodorant | 6 products |
| lipstick | 6 products |
| facial moisturizer/treatment | 5 products |
| facial cleanser | 5 products |
| baby shampoo | 5 products |
| hand cream | 5 products |
| fragrance for women | 5 products |
| body firming lotion | 4 products |
| styling gel/lotion | 4 products |
| toothpaste | 4 products |
| recreational sunscreen | 4 products |
| baby powder | 3 products |
| hair spray | 3 products |
| mask | 3 products |
| conditioner | 3 products |
| baby soap | 3 products |
| foot cleansing | 2 products |
| lip balm with SPF | 2 products |
| baby lotion | 2 products |
| shaving cream | 2 products |
| makeup primer | 2 products |
| bubble bath | 2 products |
| body powder | 2 products |
| foot moisturizer | 2 products |
| foot odor control | 2 products |
| detangler | 2 products |
| setting powder/spray | 2 products |
| beard oil | 2 products |
| hand sanitizer | 2 products |
| baby sunscreen | 1 products |
| toners/astringents | 1 products |
| anti-aging | 1 products |
| hair styling aide | 1 products |
| serums & essences | 1 products |
| mouthwash | 1 products |
| 1 products | |
| baby oil | 1 products |
| beard care | 1 products |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Irritant (eyes, skin, or lungs) | EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5 |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Persistent, bioaccumulative toxicant - Limited or emerging evidence in open scientific literature | Peer Reviewed Literature 2015. Emerging PBTs from peer-reviewed literature. Appears as: listid: PBT-PEER-038; Chemical_Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; ; CAS: 5989-27-5 |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5 |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| May cause sensitization by skin contact, with allergic reaction in skin or lungs | US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5 |
Use restrictions
| Concern | Reference |
|---|---|
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Final report 12/2016 available from CIR |
| Restricted in cosmetics - labeling requirement for allergens | EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5 |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| Developmental toxicity (significant increase in the number of fetuses with skeletal abnormalities, including lumbar ribs, fused ribs, and delayed ossification of several bones in the paws) were observed in the animals administered 2363 mg/kg/day. | 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Dangerous for the environment | EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5 |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5 |
Cancer
| Concern | Reference |
|---|---|
| IARC Group 3 (no cancer link) | IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5 |
Data gaps
| Concern | Reference |
|---|---|
| 5 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5 |
Data Sources
- EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
- Peer Reviewed Literature 2015. Emerging PBTs from peer-reviewed literature. Appears as: listid: PBT-PEER-038; Chemical_Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; ; CAS: 5989-27-5
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
- US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
- Final report 12/2016 available from CIR
- EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5
- 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.
- IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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