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GLYCYRRHIZA URALENSIS (LICORICE) ROOT EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (moderate), and Non-reproductive organ system toxicity (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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mask8 products
serums & essences5 products
facial moisturizer/treatment4 products
exfoliant/scrub3 products
toothpaste2 products
moisturizer1 products
bar soap1 products
pore strips1 products
makeup primer1 products
daily use with SPF1 products
around-eye cream1 products
toners/astringents1 products

Endocrine disruption

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Concern Reference
Licorice and its derivative substances disrupt function of the adrenal (corticosteroid hormone) axis.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Anti-androgenic effects of licorice have been observed in humans.Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
Licorice extract exhibits estrogenic activity in vitro.D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
Licorice extracts impacted pituitary hormone secretion in vitro and in vivo in rats.Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.

Developmental/reproductive toxicity

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Concern Reference
Licorice consumption during pregnancy is linked to adverse birth outcomes.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Licorice extract affected male reprodutive function in rats.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Organ system toxicity (non-reproductive)

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Concern Reference
Licorice and its constituents/derivatives affect the cardiovascular system by disrupting hormones involved in water/salt balance.Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
Effects on liver enzyme function have been observed in humans and animals.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Chronic exposure to licorice extract caused liver damage in fish.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Allergies/immunotoxicity

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Concern Reference
Licorice and its constituents/derivatives can impact immune function.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Neurotoxicity

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Concern Reference
Licorice derivatives have exhibited neuroprotective, sedative, and antidepressant effects in various studies, indicating a capacity to elicit nervous system effects.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Data gaps

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Concern Reference
341 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data Sources

  • Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
  • Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
  • D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
  • Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.
  • Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
  • Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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