EWG Skin Deep® | What is CI 21108

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Data: Limited

Ci 21108

IMAGE SOURCE: PubChem

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Other Concerns

Persistence and bioaccumulation (high) and Non-reproductive organ system toxicity (moderate)

SYNONYMS

1'-BIPHENYL)-4,4'-DIYL]BIS(AZO)BIS[N-(4-CHLORO-2,5-DIMETHOXYPHENYL)-3-OXOBUTANAMID 2,2'-[(3,3'-DICHLORO-1, 2,2'-[(3,3'-DICHLORO-1, 1'-BIPHENYL)-4,4'-DIYL]BIS(AZO)BIS[N-(4-CHLORO-2,5-DIMETHOXYPHENYL)-3-OXOBUTANAMID, 2,2'-[(3,3'-DICHLORO-1,1'-BIPHENYL)-4,4'-DIYL]BIS(AZO)BIS[N-(4-CHLORO-2,5-DIMETHOXYPHENYL)-3-OXO-, 2,2'-[(3,3'-DICHLORO[1,1'-BIPHENYL]-4,4'-DIYL)BIS(AZO)]BIS[N-(4-CHLORO-2,5-DIMETHOXYPHENYL)-3-OXOBUTYRAMIDE], ACETOACETANILIDE, 2,2"-((3,3'-DICHLORO-4,4'-BIPHENYLYLENE)BIS(AZO))BIS(4'-CHLORO-2',5'-DIMETHOXY-, BUTANAMIDE,, BUTANAMIDE, 2,2'-[(3,3'-DICHLORO[1,1'-BIPHENYL]-4,4'-DIYL)BIS(AZO)]BIS[N-(4-CHLORO-2,5-DIMETHOXYPHENYL)-3-OXO-, CI 21108, E], and PIGMENT YELLOW 83

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

CI 21108 is classed chemically as a disazo color.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
LOW

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

nail polish	2 products
bar soap	1 products

Persistence and bioaccumulation

CONCERN	REFERENCE
Persistent, bioaccumulative in wildlife and humans	Open scientific literature
Persistent or bioaccumulative and moderate to high toxicity concern in humans	Environment Canada Domestic Substance List
Persistent, bioaccumulative in wildlife	EU PTBs - PRIO database & Secondary PRIO database
Persistent, bioaccumulative in wildlife	Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as medium human health priority	Environment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Data gaps

CONCERN	REFERENCE
0 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Open scientific/peer reviewed literature
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU (European Union). 2006. Persistent, bioaccumulative chemicals identified in PRIO database - a tool for risk reduction of chemicals. Secondary PRIO database - a tool for risk reduction of chemicals. Secondary Kemi. Place Published, Kemi-Swedish Chemicals Inspectorate.
EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability