Other ConcernsUse restrictions (low), Neurotoxicity (low), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (low)
SYNONYMS1-HEXADECANAMINIUM, N,N,N-TRIMETHYL-, METHYL SULFATE, 1HEXADECANAMINIUM, N,N,NTRIMETHYL, METHYL SULFATE, AMMONIUM, HEXADECYLTRIMETHYL, METHYL SULFATE, CETRIMONIUM METHOSULFATE, CETYLTRIMETHYLAMMONIUM METHYL SULFATE, HEXADECYLTRIMETHYLAMMONIUM METHOSULFATE, HEXADECYLTRIMETHYLAMMONIUM METHYL SULPHATE, METHYL SULFATE 1-HEXADECANAMINIUM, N,N,N-TRIMETHYL-, N,N,N-TRIMETHYL- METHYL SULFATE 1-HEXADECANAMINIUM, and N,N,N-TRIMETHYL-1-HEXADECANAMINIUM METHYL SULFATE
Unacceptable: EWG VERIFIED products cannot contain this ingredient
Cetrimonium Methosulfate is a quaternary ammonium salt.
See how this product scores for common concerns.
HIGHAllergies & Immunotoxicity
LOWDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
|Known human any toxicant or allergen||Open scientific literature|
|Possible human any toxicant or allergen||Open scientific literature|
Organ system toxicity (non-reproductive)
|Possible human any toxicant||Open scientific literature|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
|One or more in vitro tests on mammalian cells demonstrate neurotoxicity||Open scientific literature|
|One or more animal studies show any effects at moderate doses||Open scientific literature|
Irritation (skin, eyes, or lungs)
|any irritation - weight of evidence unknown/unassessed||Open scientific literature|
|Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications||Cosmetic Ingredient Review Assessments|
|Associated with endocrine disruption||Open scientific literature|
|Suspected to be an environmental toxin||Environment Canada Domestic Substance List|
Persistence and bioaccumulation
|Not suspected to be persistent||Environment Canada Domestic Substance List|
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|1423 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
- Open scientific/peer reviewed literature
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.