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ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate) and Non-reproductive organ system toxicity (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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antiperspirant/deodorant3 products
antiperspirant/deodorant (men's)2 products

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyCosIng
Use is restricted in Canadian cosmetics.Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada

Cancer

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Concern Reference
This study found a relationship between use of antiperspirant product use, breast cancer risk, and aluminum concentration in breast tissue in women.Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85.
This study found that treating mouse mammary cells with aluminum chloride, at concentrations observed in human breast tissue, formed large metastatic tumors when implanted back into mice.Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790.
This small (n = 54) epidemiological study found no link between breast cancer and antiperspirant use in women.Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80.

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of any toxicityKlaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull

Data gaps

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Concern Reference
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada
  • Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85.
  • Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790.
  • Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80.
  • Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.

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