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3-HEXENOL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Endocrine disruption (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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body wash/cleanser4 products
shampoo4 products
facial cleanser3 products
beach & sport sunscreen3 products
conditioner3 products
liquid hand soap3 products
moisturizer3 products
bubble bath2 products
after sun product1 products
serums & essences1 products
fragrance for women1 products
fragrance for men1 products

Irritation (skin, eyes, or lungs)

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Concern Reference
Causes serious eye irritation.European Chemicals Agency (ECHA)

Endocrine disruption

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Concern Reference
Showed activation in cellular assays associated with endocrine disruption.National Toxicology Program (NTP)

Organ system toxicity (non-reproductive)

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Concern Reference
Increased kidney weight and urine concentration at very high doses.I F. Gaunt, J. Colley, P. Grasso, A. B. Lansdown & S. D. Gangolli. 1969. Acute (rat and mouse) and short-term (rat) toxicity studies on cis-3-hexen-1-ol. Food and cosmetics toxicology 7(5), 451-9.
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
In vitro testing indicates a lack of genotoxicity/mutagenicity.RIFM fragrance ingredient safety assessment, 3-hexen-1-ol (isomer unspecified), CAS Registry Number 544-12-7 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 110 Suppl 1, S629-S636.

Data gaps

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Concern Reference
212 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Developmental/reproductive toxicity

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Concern Reference
Very low, potentially incidental adverse effects at high exposure.RIFM fragrance ingredient safety assessment, 3-hexen-1-ol (isomer unspecified), CAS Registry Number 544-12-7 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 110 Suppl 1, S629-S636.

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Allergies/immunotoxicity

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Concern Reference
Structural analysis, animal, and human studies fail to indicate sensitization.RIFM fragrance ingredient safety assessment, 3-hexen-1-ol (isomer unspecified), CAS Registry Number 544-12-7 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 110 Suppl 1, S629-S636.

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • European Chemicals Agency (ECHA)
  • National Toxicology Program (NTP)
  • I F. Gaunt, J. Colley, P. Grasso, A. B. Lansdown & S. D. Gangolli. 1969. Acute (rat and mouse) and short-term (rat) toxicity studies on cis-3-hexen-1-ol. Food and cosmetics toxicology 7(5), 451-9.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • RIFM fragrance ingredient safety assessment, 3-hexen-1-ol (isomer unspecified), CAS Registry Number 544-12-7 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 110 Suppl 1, S629-S636.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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