IMAGE SOURCE: PubChem
Other ConcernsUse restrictions (high), Ecotoxicology (low), and Occupational hazards (high)
SYNONYMS1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE, 1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE (1:1), 2,5-DIAMINOTOLUENE SULFATE, 2-METHYL- SULFATE 1,4-BENZENEDIAMINE, 2-METHYL-1,4-BENZENEDIAMINE SULFATE, P-TOLUENEDIAMINE SULFATE, SULFATE 1,4-BENZENEDIAMINE, 2-METHYL-, and TOLUENE-2,5-DIAMINE SULFATE
Unacceptable: EWG VERIFIED products cannot contain this ingredient
Toluene-2, 5-Diamine Sulfate is a substituted aromatic amine salt.
See how this product scores for common concerns.
HIGHAllergies & Immunotoxicity
LOWDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
|hair color and bleaching||97 products|
|brow liner||1 products|
|Violation of government restrictions - Banned or found unsafe for use in cosmetics||Canada - Prohibited and Restricted Cosmetics Ingredients|
|Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any||Open scientific literature|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any||CosIng|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any||Open scientific literature|
|Determined safe for use in cosmetics, subject to concentration or use limitations - any||CTFA International Cosmetic Ingredient Dictionary and Handbook|
|Known human any toxicant or allergen||Open scientific literature|
|Human skin toxicant or allergen - strong evidence||Cosmetic Ingredient Review Assessments|
|Limited evidence of immune system toxicity or allergies||CPS&Q - Classification & Labelling|
|Limited evidence of any toxicity or allergies||Open scientific literature|
|Allowed workplace exposures restricted to low doses||CPS&Q - Classification & Labelling|
|Limited evidence of carcinogenicity||Open scientific literature|
|Cancer - limited evidence||CTFA International Cosmetic Ingredient Dictionary and Handbook|
|Not likely to be carcinogenic in humans||Open scientific literature|
Organ system toxicity (non-reproductive)
|Classified as toxic or harmful||CPS&Q - Classification & Labelling|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
|Wildlife and environmental toxicity||CPS&Q - Classification & Labelling|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|Insufficient data to determine safety||Cosmetic Ingredient Review Assessments|
|37 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
Persistence and bioaccumulation
|Not suspected to be persistent||Environment Canada Domestic Substance List|
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Cosmetic Ingredient Review Assessments|
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- Open scientific/peer reviewed literature
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.