EWG Skin Deep® | What is TOLUENE-2,5-DIAMINE SULFATE

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED™

Data: Fair

Toluene 2,5 Diamine Sulfate

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high), Ecotoxicology (low), and Occupational hazards (high)

SYNONYMS

1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE, 1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE (1:1), 2,5-DIAMINOTOLUENE SULFATE, 2-METHYL- SULFATE 1,4-BENZENEDIAMINE, 2-METHYL-1,4-BENZENEDIAMINE SULFATE, P-TOLUENEDIAMINE SULFATE, SULFATE 1,4-BENZENEDIAMINE, 2-METHYL-, and TOLUENE-2,5-DIAMINE SULFATE

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

Toluene-2, 5-Diamine Sulfate is a substituted aromatic amine salt.

Common concerns

See how this product scores for common concerns.

MODERATE

Cancer
HIGH

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

hair color and bleaching	97 products
brow liner	1 products
toners/astringents	1 products

Use restrictions

CONCERN	REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmetics	Canada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any	Open scientific literature
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any	CosIng
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any	Open scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - any	CTFA International Cosmetic Ingredient Dictionary and Handbook

Allergies/immunotoxicity

CONCERN	REFERENCE
Known human any toxicant or allergen	Open scientific literature
Human skin toxicant or allergen - strong evidence	Cosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergies	CPS&Q - Classification & Labelling
Limited evidence of any toxicity or allergies	Open scientific literature

Occupational hazards

CONCERN	REFERENCE
Allowed workplace exposures restricted to low doses	CPS&Q - Classification & Labelling

Cancer

CONCERN	REFERENCE
Limited evidence of carcinogenicity	Open scientific literature
Cancer - limited evidence	CTFA International Cosmetic Ingredient Dictionary and Handbook
Not likely to be carcinogenic in humans	Open scientific literature

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as toxic or harmful	CPS&Q - Classification & Labelling
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Ecotoxicology

CONCERN	REFERENCE
Wildlife and environmental toxicity	CPS&Q - Classification & Labelling
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Data gaps

CONCERN	REFERENCE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product	Cosmetic Ingredient Review Assessments
Insufficient data to determine safety	Cosmetic Ingredient Review Assessments
37 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be persistent	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any	Cosmetic Ingredient Review Assessments

Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Open scientific/peer reviewed literature
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability