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POLYSORBATE-80

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Non-reproductive organ system toxicity (low) and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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mask77 products
serums & essences58 products
facial moisturizer/treatment51 products
daily use with SPF39 products
mouthwash37 products
toothpaste34 products
moisturizer33 products
bath oil/salts/soak29 products
bronzer/highlighter28 products
hair styling aide22 products
around-eye cream19 products
hair treatment/serum18 products
facial cleanser18 products
body firming lotion18 products
body wash/cleanser16 products
conditioner15 products
makeup primer14 products
shampoo12 products
hair spray12 products
mascara12 products
concealer12 products
exfoliant/scrub11 products
eye liner11 products
brow liner10 products
blush10 products
recreational sunscreen10 products
styling gel/lotion10 products
toners/astringents9 products
BB cream8 products
after sun product7 products
lipstick7 products
anti-aging7 products
hand cream7 products
facial powder6 products
lip balm with SPF6 products
makeup remover6 products
sunless tanning5 products
foundation4 products
baby shampoo3 products
styling mousse/foam3 products
baby soap3 products
baby sunscreen2 products
baby oil2 products
after shave2 products
2 products
beard care2 products
bar soap2 products
hair color and bleaching2 products
detangler2 products
liquid hand soap2 products
lip balm1 products
lip plumper1 products
foot cleansing1 products
damaged skin treatment1 products
tooth whitening1 products
foot odor control1 products
foot moisturizer1 products
bubble bath1 products
baby lotion1 products
baby bubble bath1 products
fragrance for women1 products
oil controller1 products
other eye makeup1 products

Contamination concerns

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Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of sense organ toxicityHarvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
122419 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • Harvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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