P-AMINOPHENOL
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Occupational hazards (high)
Cancer 

Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity 

Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity 

Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
hair color and bleaching | 84 products |
Occupational hazards
Concern | Reference |
---|---|
Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Limited evidence of occupational hazards | CPS&Q - Classification & Labelling |
Allergies/immunotoxicity
Concern | Reference |
---|---|
Human skin toxicant or allergen - strong evidence | JACT 7(3):279-333, 1988 confirmed 09/05 |
Human skin toxicant or allergen - strong evidence | CIR |
Limited evidence of immune system toxicity or allergies | National Library of Medicine HazMap |
Organ system toxicity (non-reproductive)
Concern | Reference |
---|---|
Classified as a high human health priority | Environment Canada Domestic Substance List |
Classified as toxic or harmful | CPS&Q - Classification & Labelling |
Limited evidence of cardiovascular or blood toxicity | National Library of Medicine HazMap |
Limited evidence of kidney toxicity | Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996. |
Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Use restrictions
Concern | Reference |
---|---|
Banned in Canadian cosmetics used around the eyes. | Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011. |
Determined safe for use in cosmetics, subject to concentration or use limitations - any | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Cancer
Concern | Reference |
---|---|
Cancer - limited evidence | EWG Assessment of Open Scientific Literature |
Cancer - limited evidence | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Mutagen - limited evidence | CPS&Q - Classification & Labelling |
Ecotoxicology
Concern | Reference |
---|---|
Wildlife and environmental toxicity | CPS&Q - Classification & Labelling |
Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
Concern | Reference |
---|---|
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | JACT 7(3):279-333, 1988 confirmed 09/05 |
Insufficient data to determine safety | Final Report 3/04 Available from CIR |
1215 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
Concern | Reference |
---|---|
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | JACT 7(3):279-333, 1988 confirmed 09/05 |
Persistence and bioaccumulation
Concern | Reference |
---|---|
Not suspected to be persistent | Environment Canada Domestic Substance List |
Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- JACT 7(3):279-333, 1988 confirmed 09/05
- CIR
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996.
- Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- EWG Assessment of Open Scientific Literature
- Final Report 3/04 Available from CIR
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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