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OCTOCRYLENE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Persistence and bioaccumulation (low), Irritation (skin, eyes, or lungs) (low), and Biochemical or cellular level changes (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| beach & sport sunscreen | 376 products |
| moisturizer with SPF | 169 products |
| lip gloss | 29 products |
| lip balm with SPF | 26 products |
| baby sunscreen | 13 products |
| body spray | 10 products |
| 9 products | |
| fragrance for women | 8 products |
| makeup with SPF | 5 products |
| nail treatment | 5 products |
| BB cream | 4 products |
| lipstick | 4 products |
| concealer | 3 products |
| makeup primer | 2 products |
| moisturizer | 1 products |
| lip balm | 1 products |
| tanning oil | 1 products |
| CC cream | 1 products |
| hair treatment/serum | 1 products |
Enhanced skin absorption
| Concern | Reference |
|---|---|
| Absorbed through human skin in vitro at 0 to 0.25% | {Hayden, 2005; Potard, 2000} |
Biochemical or cellular level changes
| Concern | Reference |
|---|---|
| Produces damaging reactive oxygen species upon exposure to sunlight | {Allen, 1996} |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Ingredient is suspected or measured to accumulate in people | Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7. |
| Found to accumulate in fish living downstream of wastewater treatment plants | Buser HR, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431. |
| Not suspected to be persistent | Environment Canada Domestic Substance List |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Limited evidence of skin irritation | de Groot AC, Roberts DW 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Accumulation in fish in Swiss rivers downstream from Wastewater Treatment Plants. | Buser H-R, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431. |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| 14937 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data Sources
- {Hayden, 2005; Potard, 2000}
- {Allen, 1996}
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
- Buser HR, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- de Groot AC, Roberts DW 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204.
- Buser H-R, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
