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OCTOCRYLENE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Persistence and bioaccumulation (low), Irritation (skin, eyes, or lungs) (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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beach & sport sunscreen408 products
moisturizer with SPF160 products
lip balm with SPF32 products
lip gloss28 products
baby sunscreen16 products
body spray3 products
makeup with SPF2 products
lipstick2 products
after shave2 products
tanning oil1 products
BB cream1 products
fragrance for women1 products
moisturizer1 products
hair treatment/serum1 products
nail treatment1 products

Enhanced skin absorption

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Concern Reference
Absorbs into the skin{Hayden, 2005; Potard, 2000}

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.{Allen, 1996}

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)Japan's Standards for Cosmetics

Persistence and bioaccumulation

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Concern Reference
Ingredient is suspected or measured to accumulate in peopleSchlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
Found to be persistent and bioaccumulative in wildlifeBuser HR, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431.
Not suspected to be persistentEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

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Concern Reference
Limited evidence of skin irritationde Groot AC, Roberts DW 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204.

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityBuser H-R, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431.
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
14937 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

  • {Hayden, 2005; Potard, 2000}
  • {Allen, 1996}
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
  • Buser HR, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • de Groot AC, Roberts DW 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204.
  • Buser H-R, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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