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OCTOCRYLENE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Persistence and bioaccumulation (low), Irritation (skin, eyes, or lungs) (low), and Biochemical or cellular level changes (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| beach & sport sunscreen | 408 products |
| moisturizer with SPF | 160 products |
| lip balm with SPF | 32 products |
| lip gloss | 28 products |
| baby sunscreen | 16 products |
| body spray | 3 products |
| makeup with SPF | 2 products |
| lipstick | 2 products |
| after shave | 2 products |
| tanning oil | 1 products |
| BB cream | 1 products |
| fragrance for women | 1 products |
| moisturizer | 1 products |
| hair treatment/serum | 1 products |
| nail treatment | 1 products |
Enhanced skin absorption
| Concern | Reference |
|---|---|
| Absorbs into the skin | {Hayden, 2005; Potard, 2000} |
Biochemical or cellular level changes
| Concern | Reference |
|---|---|
| Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease. | {Allen, 1996} |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Ingredient is suspected or measured to accumulate in people | Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7. |
| Found to be persistent and bioaccumulative in wildlife | Buser HR, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431. |
| Not suspected to be persistent | Environment Canada Domestic Substance List |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Limited evidence of skin irritation | de Groot AC, Roberts DW 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Wildlife and environmental toxicity | Buser H-R, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431. |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| 14937 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data Sources
- {Hayden, 2005; Potard, 2000}
- {Allen, 1996}
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
- Buser HR, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various swiss rivers with inputs from wastewater treatment plants. Environmental Science & Technology 40(5): 1427-1431.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- de Groot AC, Roberts DW 2014. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 70(14):193-204.
- Buser H-R, Balmer ME, Schmid P, Kohler M 2006. Occurrence of UV Filters 4-Methylbenzylidene Camphor andOctocrylene in Fish from Various Swiss Rivers with Inputs from Wastewater Treatment Plants. ES&T. 40:1427-1431.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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