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ISOBUTYLPARABEN

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (high), and Biochemical or cellular level changes (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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eye liner16 products
blush11 products
lip liner6 products
facial moisturizer/treatment6 products
styling mousse/foam3 products
foundation3 products
sunless tanning3 products
eye shadow3 products
anti-aging3 products
damaged skin treatment2 products
makeup primer2 products
recreational sunscreen2 products
styling gel/lotion2 products
body powder1 products
lip gloss1 products
hair relaxer1 products
brow liner1 products
mask1 products
hair treatment/serum1 products
hair styling aide1 products
baby sunscreen1 products
facial cleanser1 products
polish remover1 products
mascara1 products
moisturizer1 products
conditioner1 products
daily use with SPF1 products
hair spray1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsEuropean Union - Banned or Restricted in Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyOpen scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - anyCosmetic Ingredient Review Assessments
Determined safe for use in cosmetics, subject to concentration or use limitations - anyOpen scientific literature

Endocrine disruption

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Concern Reference
Known human any disruptorOpen scientific literature
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
Limited evidence of endocrine disruptionOpen scientific literature
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
One or more studies show weak endocrine disruptionEWG Assessment of Open Scientific Literature
One or more animal studies show endocrine disruption at moderate dosesOpen scientific literature
One or more studies show weak endocrine disruptionOpen scientific literature
One or more animal studies show endocrine disruption at high dosesOpen scientific literature

Developmental/reproductive toxicity

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Concern Reference
Possible human reproductive or developmental toxinOpen scientific literature
One or more animal studies show any effects at very low dosesOpen scientific literature

Allergies/immunotoxicity

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Concern Reference
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
One or more human case studies show possible immune or allergenic effectsOpen scientific literature

Biochemical or cellular level changes

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Concern Reference
Interferes with gene expresionOpen scientific literature

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Safety assessment was based on related chemicalCosmetic Ingredient Review Assessments
29 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • EC (European Commission of the European Union). 1999-2006. Enterprise Directorate-General Pharmaceuticals and Cosmetics. The rules governing cosmetic products in the European Union, Volume 1, "Cosmetics legislation."
  • Open scientific/peer reviewed literature
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • EWG Assessment of Open Scientific Literature
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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