Menu Close Menu

Menu

GLYCYRRHIZA GLABRA (LICORICE) ROOT

Score:

Data: Limited

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

Expand content Collapse content
facial cleanser6 products
facial moisturizer/treatment5 products
hair treatment/serum4 products
toothpaste3 products
exfoliant/scrub3 products
makeup remover2 products
mask2 products
serums & essences2 products
toners/astringents1 products
styling gel/lotion1 products
hair styling aide1 products
antiperspirant/deodorant1 products
conditioner1 products
anti-aging1 products
bar soap1 products
shampoo1 products
lip balm1 products
baby lotion1 products

Endocrine disruption

Expand content Collapse content
Concern Reference
Licorice and its derivative substances disrupt function of the adrenal (corticosteroid hormone) axis.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Anti-androgenic effects of licorice have been observed in humans.Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
Licorice extract exhibits estrogenic activity in vitro.D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
Licorice extracts impacted pituitary hormone secretion in vitro and in vivo in rats.Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.

Developmental/reproductive toxicity

Expand content Collapse content
Concern Reference
Licorice consumption during pregnancy is linked to adverse birth outcomes.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Licorice extract affected male reprodutive function in rats.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Licorice and its constituents/derivatives affect the cardiovascular system by disrupting hormones involved in water/salt balance.Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
Effects on liver enzyme function have been observed in humans and animals.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Chronic exposure to licorice extract caused liver damage in fish.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Allergies/immunotoxicity

Expand content Collapse content
Concern Reference
Licorice and its constituents/derivatives can impact immune function.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Neurotoxicity

Expand content Collapse content
Concern Reference
Licorice derivatives have exhibited neuroprotective, sedative, and antidepressant effects in various studies, indicating a capacity to elicit nervous system effects.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Data gaps

Expand content Collapse content
Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
309 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

Expand content Collapse content
Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
  • Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
  • D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
  • Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.
  • Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
  • Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer