Other ConcernsUse restrictions (moderate), Persistence and bioaccumulation (moderate), and Irritation (skin, eyes, or lungs) (low)
SYNONYMS1,1'-HEXAMETHYLENE BIS(5-(P-CHLOROPHENYL)BIGUANIDE) DIHYDROCHLORIDE, 2,4,11,13-TE TRAAZATETRADECANEDIIMIDAMIDE, N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-, DIHYDROCHLORIDE, CHLORHEXIDINE DIHYDROCHLORIDE, CHLORHEXIDINE HYDROCHLORIDE, CHLORHEXIDINIUM DICHLORIDE, DIHYDROCHLORIDE 2,4,11,13-TE TRAAZATETRADECANEDIIMIDAMIDE, N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-, DIHYDROCHLORIDE N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, N,N''-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, DIHYDROCHLORIDE, N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO- DIHYDROCHLORIDE 2,4,11,13-TE TRAAZATETRADECANEDIIMIDAMIDE, and N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, DIHYDROCHLORIDE
Unacceptable: EWG VERIFIED products cannot contain this ingredient
Chlorhexidine is a synthetic preservative and antiseptic.
See how this product scores for common concerns.
MODERATEAllergies & Immunotoxicity
LOWDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
Persistence and bioaccumulation
|Persistent or bioaccumulative and moderate to high toxicity concern in humans||Open scientific literature|
|Human any toxicant or allergen - strong evidence||Open scientific literature|
|Human immune and respiratory toxicant or allergen - strong evidence||Association of Occupational and Environmental Clinics|
|Limited evidence of immune system toxicity or allergies||National Library of Medicine HazMap|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)||Japan's Standards for Cosmetics|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics||Canada - Prohibited and Restricted Cosmetics Ingredients|
|Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications||Cosmetic Ingredient Review Assessments|
Irritation (skin, eyes, or lungs)
|Limited evidence of skin irritation||National Library of Medicine HazMap|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|6264 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
Multiple, additive exposure sources
|Designated as safe for general or specific, limited use in food||FDA Food Additive Status|
- Open scientific/peer reviewed literature
- AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
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