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Data: Fair

Chlorhexidine Dihydrochloride

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Use restrictions (moderate), Persistence and bioaccumulation (moderate), and Irritation (skin, eyes, or lungs) (low)

SYNONYMS

1,1'-HEXAMETHYLENE BIS(5-(P-CHLOROPHENYL)BIGUANIDE) DIHYDROCHLORIDE, 2,4,11,13-TE TRAAZATETRADECANEDIIMIDAMIDE, N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-, DIHYDROCHLORIDE, CHLORHEXIDINE DIHYDROCHLORIDE, CHLORHEXIDINE HYDROCHLORIDE, CHLORHEXIDINIUM DICHLORIDE, DIHYDROCHLORIDE 2,4,11,13-TE TRAAZATETRADECANEDIIMIDAMIDE, N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-, DIHYDROCHLORIDE N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, N,N''-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, DIHYDROCHLORIDE, N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO- DIHYDROCHLORIDE 2,4,11,13-TE TRAAZATETRADECANEDIIMIDAMIDE, and N,N'-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, DIHYDROCHLORIDE

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


Chlorhexidine is a synthetic preservative and antiseptic.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • MODERATE
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • MODERATE
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
conditioner40 products
hair color and bleaching22 products
hair treatment/serum8 products
hair styling aide3 products
mask1 products
detangler1 products

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humansOpen scientific literature

Allergies/immunotoxicity

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CONCERN REFERENCE
Human any toxicant or allergen - strong evidenceOpen scientific literature
Human immune and respiratory toxicant or allergen - strong evidenceAssociation of Occupational and Environmental Clinics
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

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CONCERN REFERENCE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)

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CONCERN REFERENCE
Limited evidence of skin irritationNational Library of Medicine HazMap

Data gaps

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CONCERN REFERENCE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
6264 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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CONCERN REFERENCE
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
  • Open scientific/peer reviewed literature
  • AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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