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BHA

Score:

Data: Robust

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Endocrine disruption (moderate), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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lipstick34 products
concealer15 products
diaper cream3 products
moisturizer with SPF2 products
eye shadow1 products
facial moisturizer/treatment1 products
bronzer/highlighter1 products
serums & essences1 products

Cancer

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Concern Reference
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Limited evidence of carcinogenicityWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 40, Suppl. 7 ;1987

Endocrine disruption

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Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyIllinois EPA Chemicals Associated with Endocrine System
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyJobling et al 1995

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as a high human health priorityEnvironment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeOSPAR PBTs - Substances of Possible Concern
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show significant any or allergenic effectsNational Library of Medicine HazMap

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityIllinois EPA Chemicals Associated with Endocrine System
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productJACT 3(5):83-146, 1984
2332 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyJACT 3(5):83-146, 1984

Data Sources

  • NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 40, Suppl. 7 ;1987
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • Illinois EPA (Illinois Environmental Protection Agency). 2000. Preliminary list of chemicals associated with endocrine system effects in animals and humans (*) or in vitro (+). In EPA (U.S. Environmental Protection Agency) 2000. Handbook for Non-Cancer Health Effects Valuation, Appendix C.
  • Jobling et al 1995
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • JACT 3(5):83-146, 1984
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.

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