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ANTHEMIS NOBILIS (CHAMOMILE)

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Neurotoxicity (low), Non-reproductive organ system toxicity (low), Multiple, additive exposure sources (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial moisturizer/treatment6 products
facial cleanser5 products
moisturizer with SPF4 products
shampoo3 products
serums & essences3 products
exfoliant/scrub2 products
moisturizer2 products
bar soap2 products
diaper cream2 products
body wash/cleanser2 products
hair treatment/serum2 products
after shave1 products
baby soap1 products
facial powder1 products
bath oil/salts/soak1 products
mask1 products
around-eye cream1 products
baby lotion1 products
baby shampoo1 products
liquid hand soap1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerIJT 18(S3):33-40, 1999

Allergies/immunotoxicity

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Concern Reference
Known human any toxicant or allergenAOEC Asthmagen list, AOEC
Human any toxicant or allergen - strong evidenceAOEC (Association of Occupational and Environmental Clinics) 2012. Asthmagen compilation - AEOC exposures codes.
One or more human case studies show equivocal any or allergenic effectsB C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
Limited evidence of any toxicity or allergiesEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Multiple, additive exposure sources

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Concern Reference
Used in food or as an additive with limited or no toxicity information availableFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Developmental/reproductive toxicity

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Concern Reference
One or more human case studies show equivocal any effectsLaura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.

Irritation (skin, eyes, or lungs)

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Concern Reference
Limited evidence of any irritationEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as toxic or harmful.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Neurotoxicity

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Concern Reference
One or more animal studies show neuromuscular effects at high doses Zsolt Sándor, Loránd Barthó, Róbert Papp, Dezső Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & Dezső Csupor 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323.

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 18(S3):33-40, 1999
730 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyIJT 18(S3):33-40, 1999

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List

Data Sources

  • IJT 18(S3):33-40, 1999
  • AOEC Asthmagen list, AOEC
  • AOEC (Association of Occupational and Environmental Clinics) 2012. Asthmagen compilation - AEOC exposures codes.
  • B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
  • European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Zsolt Sándor, Loránd Barthó, Róbert Papp, DezsÅ‘ Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & DezsÅ‘ Csupor 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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