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ANTHEMIS NOBILIS (CHAMOMILE)

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Non-reproductive organ system toxicity (low), Multiple, additive exposure sources (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial moisturizer/treatment6 products
body wash/cleanser5 products
moisturizer5 products
shampoo4 products
facial cleanser4 products
hair treatment/serum3 products
serums & essences3 products
bath oil/salts/soak2 products
mask2 products
conditioner2 products
exfoliant/scrub2 products
bar soap2 products
diaper cream2 products
lip balm1 products
around-eye cream1 products
baby lotion1 products
baby shampoo1 products
beach & sport sunscreen1 products
liquid hand soap1 products
after shave1 products
moisturizer with SPF1 products
baby soap1 products
facial powder1 products

Allergies/immunotoxicity

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Concern Reference
Known human any toxicant or allergenAOEC Asthmagen list, AOEC
Human immune and respiratory toxicant or allergen - strong evidenceAssociation of Occupational and Environmental Clinics
Asthmagen sensitizer [Asthmagen, sensitizer induced according to Review by the Association of Occupational and Environmental Clinics (AOEC)] AOEC (Association of Occupational and Environmental Clinics) 2012. Asthmagen compilation - AEOC exposures codes.
Allergic skin reaction observed in human case study.B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
May cause an allergic skin reaction.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Multiple, additive exposure sources

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Concern Reference
Used in food or as an additive with limited or no toxicity information availableFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Developmental/reproductive toxicity

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Concern Reference
Weak evidence of possible pregnancy/birth effects associated with chamomile consumption.Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.

Irritation (skin, eyes, or lungs)

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Concern Reference
Causes skin irritationEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Organ system toxicity (non-reproductive)

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Concern Reference
May be fatal if swallowed and enters airwaysEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Neurotoxicity

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Concern Reference
Derivatives of this species demonstrate neuromuscular effects in animals. Zsolt Sándor, Loránd Barthó, Róbert Papp, Dezső Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & Dezső Csupor 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323.

Ecotoxicology

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Concern Reference
toxic to aquatic life with long lasting effectsEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
730 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List

Data Sources

  • AOEC Asthmagen list, AOEC
  • AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
  • AOEC (Association of Occupational and Environmental Clinics) 2012. Asthmagen compilation - AEOC exposures codes.
  • B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
  • European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Zsolt Sándor, Loránd Barthó, Róbert Papp, DezsÅ‘ Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & DezsÅ‘ Csupor 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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