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4-CHLORORESORCINOL
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| hair color and bleaching | 16 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| European SCCS 4-chlororesorcinol is a moderate sensitizer. | Scientific Committee on Consumer Safety (SCCS) 2010. Opinion on 4-Chlororesorcinol COLIPA n° A12. SCCS/1224/09, July 2010. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_016.pdf |
| Human Sensitizer toxicant or allergen - moderate evidence | EWG Assessment of Open Scientific Literature |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | JACT 15(4): 284-94, 1996 |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | CTFA International Cosmetic Ingredient Dictionary and Handbook |
| Use in hair dye does not pose a risk to the health of the consumer, apart from its moderate skin sensitizing potential. | Scientific Committee on Consumer Safety (SCCS) 2010. Opinion on 4-Chlororesorcinol COLIPA n° A12. SCCS/1224/09, July 2010. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_016.pdf |
Cancer
| Concern | Reference |
|---|---|
| Cancer - limited evidence | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Data gaps
| Concern | Reference |
|---|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | JACT 15(4): 284-94, 1996 |
| 15 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | JACT 15(4): 284-94, 1996 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- Scientific Committee on Consumer Safety (SCCS) 2010. Opinion on 4-Chlororesorcinol COLIPA n° A12. SCCS/1224/09, July 2010. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_016.pdf
- EWG Assessment of Open Scientific Literature
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- JACT 15(4): 284-94, 1996
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
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