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Data: Limited

4 Amino 2 Hydroxytoluene

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Use restrictions (moderate)

SYNONYMS

4-AMINO-2-HYDROXY-1-METHYLBENZENE, 4-AMINO-2-HYDROXYTOLUENE, 5-AMINO-2-METHYL- PHENOL, 5-AMINO-2-METHYLPHENOL, 5-AMINO-O-CRESOL, P-AMINO-O-CRESOL, PHENOL, 5-AMINO-2-METHYL-, and PHENOL, 5AMINO2METHYL

4-Amino-2-Hydroxytoluene is a substituted aromatic compound.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • MODERATE
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reingredientive Toxicity
  • MODERATE
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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hair color and bleaching51 products
brow liner1 products

Allergies/immunotoxicity

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CONCERN REFERENCE
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human skin toxicant or allergen - strong evidenceEWG Assessment of Open Scientific Literature

Use restrictions

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CONCERN REFERENCE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyCosIng
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyOpen scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - anyCTFA International Cosmetic Ingredient Dictionary and Handbook

Cancer

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CONCERN REFERENCE
Cancer - limited evidenceCTFA International Cosmetic Ingredient Dictionary and Handbook
Cancer - limited evidenceEWG Assessment of Open Scientific Literature

Data gaps

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CONCERN REFERENCE
Insufficient data to determine safetyCosmetic Ingredient Review Assessments
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Considered safe based on assumption of low absorptionCosmetic Ingredient Review Assessments
14 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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CONCERN REFERENCE
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • EWG Assessment of Open Scientific Literature
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Open scientific/peer reviewed literature
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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