Evidence
Health issue
Level of Concern
Source
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Only in: Household Cleaners
low
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
A review article reports this substance is not mutagenic
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
A review article reports that terpenes may have anticancer properties.
low
Girija Kuttan, Poyil Pratheeshkumar, Kanjoormana Aryan Manu & Ramadasan Kuttan. 2011. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical biology 49(10), 995-1007.
Component: CITRAL
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
Component: TERPENES
A review article reports that terpenes may have anticancer properties.
A review article reports that terpenes may have anticancer properties.
low
Girija Kuttan, Poyil Pratheeshkumar, Kanjoormana Aryan Manu & Ramadasan Kuttan. 2011. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical biology 49(10), 995-1007.
A review article reports this substance may have anticarcinogenic activity
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
A peer-reviewed study reports that botanical oils prevent oxidative damage.
low
Kevin P. Anthony, Suziat A. Deolu-Sobogun & Mahmoud A. Saleh. 2012. Comprehensive assessment of antioxidant activity of essential oils. Journal of food science 77(8), C839-43.
Causes serious eye damage
Only in: Household Cleaners
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Component: CITRAL
NTP Toxcast scored 2.5-3.5
NTP Toxcast scored 2.5-3.5
some
EWG Toxcast Analysis - National Toxicology Program (NTP)
Component: CITRAL
The National Toxicology Program reports this substances may cause hyperplasia in laboratory animals at high doses.
Only in: Food Scores®
The National Toxicology Program reports this substances may cause hyperplasia in laboratory animals at high doses.
Only in: Food Scores®
some
National Toxicology Program. 2003. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 505 NIH Publication No. 03-4439.
Component: CITRAL
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Component: CITRAL
The ACGIH reports this substance causes upper respiratory tract irritation.
The ACGIH reports this substance causes upper respiratory tract irritation.
some
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
some
Opinion on Frangrance allergens in cosmetics (2011) - EU Cosmetics Directive
Component: CITRAL
May cause an allergic skin reaction
Only in: Household Cleaners
May cause an allergic skin reaction
Only in: Household Cleaners
some
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Component: CITRAL
Recognized by the European Union as a skin allergen
Recognized by the European Union as a skin allergen
some
Allergen list - EU Cosmetics Directive
Component: CITRAL
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
some
Opinion on Frangrance allergens in cosmetics (2011) - EU Cosmetics Directive
Component: CITRAL
The National Toxicology Program reports this substances may cause kidney toxicity in laboratory animals at high doses.
Only in: Food Scores®
The National Toxicology Program reports this substances may cause kidney toxicity in laboratory animals at high doses.
Only in: Food Scores®
some
National Toxicology Program. 2003. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 505 NIH Publication No. 03-4439.
