Health issue
Level of Concern
Source
The US EPA reports the LC50 value is very toxic to aquatic life.
high
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The US EPA reports this substance is a skin sensitizer.
some
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The peer-reviewed study reports methylchloroisothiazolinone is mutagenic
some
T. H. Connor, P. G. Tee, M. Afshar & K. M. Connor. 1996. Mutagenicity of cosmetic products containing Kathon. Environmental and molecular mutagenesis 28(2), 127-32.
NIOSH reports that this substance is a skin sensitizer.
some
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
The US EPA reports this substance causes skin irritation.
some
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
A review article reports that this substance causes contact allergies.
some
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
A review article reports that this substance is a skin sensitizer.
some
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
NIOSH reports that this substance is a skin irritant.
some
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
Organohalogen compounds are often found to be persistent in the environment, bioaccumulative, and associated with chronic health concerns
some
Prasada Rao S. Kodavanti & Bommanna G. Loganathan. 2017. Organohalogen Pollutants and Human Health. International Encyclopedia of Public Health, 359-366.
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
A peer-reviewed study reports that this substance causes allergic contact dermatitis.
some
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
A peer-reviewed study reports that this substance is a skin sensitizer.
some
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
A peer-reviewed study reports that this substance is a skin sensitizer.
some
D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.
A peer-reviewed study reports this substance causes dermatitis.
some
Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.
The US EPA reports it is unknown if this substance is carcinogenic.
low
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.
low
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.