developmentb
D

FD&C YELLOW NO. 5 (CI 19140)

 
This substance ranges from C to D depending on concentration/usage.
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
No Data, Some Concern
 
Developmental &
Reproductive Toxicity
 
Low Concern
 
Cancer
 
Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of general systemic/organ effects; cancer; kidney and urinary effects
FD&C Yellow No. 5 (CI 19140) can be found in 99 products.
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Evidence

Health issue
 
Level of Concern
 
Source
EFSA finds that there is "limited evidence" that Yellow 5 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population."
Only in: Food Scores®
 
moderate
 
European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation Tartrazine (E 102). EFSA Journal 7(11), 1331.
European Food Safety Authority reviewed study of children ingesting food colorings and concluded that it provided "limited evidence" that the mixture had a small and statistically significant effect on activity and attention in children.
Only in: Food Scores®
 
moderate
 
European Food Safety Authority & Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC). 2008. Assessment of the results of the study by McCann et al. (2007) on the effect of some colours and sodium benzoate on children’s behaviour, Question No EFSA-Q-2007-171. EFSA Journall 660, 1.
EFSA finds that there is "limited evidence" that Yellow 5 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population."
Only in: Food Scores®
 
moderate
 
European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation Tartrazine (E 102). EFSA Journal 7(11), 1331.
European Food Safety Authority reviewed study of children ingesting food colorings and concluded that it provided "limited evidence" that the mixture had a small and statistically significant effect on activity and attention in children.
Only in: Food Scores®
 
moderate
 
European Food Safety Authority & Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC). 2008. Assessment of the results of the study by McCann et al. (2007) on the effect of some colours and sodium benzoate on children’s behaviour, Question No EFSA-Q-2007-171. EFSA Journall 660, 1.
Review article concluded that chemical can cause hyperactivity in children.
 
some
 
Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46. - Peer Reviewed Literature
Review article concluded that chemical can cause hyperactivity in children.
 
some
 
Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46. - Peer Reviewed Literature
EFSA concludes that some sensitive individuals may experience allergic reactions at dose levels within the ADI.
Only in: Food Scores®
 
some
 
European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation Tartrazine (E 102). EFSA Journal 7(11), 1331.
EFSA concludes that some sensitive individuals may experience allergic reactions at dose levels within the ADI.
Only in: Food Scores®
 
some
 
European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation Tartrazine (E 102). EFSA Journal 7(11), 1331.
A review article conclused that this substance may be carcinogenic at high or cumulative exposures, which are unlikely to occur.
 
some
 
Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22. - Peer Reviewed Literature
A peer-reviewed study reports this substance shows estrogenic activity in a human cell line.
Only in: Food Scores®
 
some
 
Andrew Axon, Felicity E. B. May, Luke E. Gaughan, Faith M. Williams, Peter G. Blain & Matthew C. Wright. 2012. Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology 298(1-3), 40-51.
Ingestion of tartrazine was associated with behavioral changes in irritability, restlessness, and sleep disturbance in some children.
Only in: Food Scores®
 
some
 
K. S. Rowe & K. J. Rowe. 1994. Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. The Journal of pediatrics 125(5 Pt 1), 691-8.
Eating a mix of artificial colors with sodium benzoate result in increased hyperactivity in 3-year-old and 8/9-year-old children in the general population.
Only in: Food Scores®
 
some
 
Donna McCann, John O. Warner, Edmund Sonuga-Barke, Emily Prince, Lucy Porteous, Kris Lok, Elizabeth Kitchin, Kate Grimshaw, Lindy Dalen, Debbie Crumpler, Alison Cooper, Angelina Barrett & Jim Stevenson. 2007. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet 370(9598), 1560-7.
A review article conclused that this substance may be carcinogenic at high or cumulative exposures, which are unlikely to occur.
 
some
 
Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22. - Peer Reviewed Literature
A peer-reviewed study found that this substance caused neurobehavioral effects in animals at high doses.
Only in: Food Scores®
 
some
 
Toyohito Tanaka. 2006. Reproductive and neurobehavioural toxicity study of tartrazine administered to mice in the diet. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 44(2), 179-87.
A peer-reviewed study found that this substance caused neurobehavioral effects in animals at high doses.
Only in: Food Scores®
 
some
 
Toyohito Tanaka, Osamu Takahashi, Shinshi Oishi & Akio Ogata. 2008. Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice. Reproductive toxicology (Elmsford, N.Y.) 26(2), 156-63.
A peer-reviewed study reports this substance shows estrogenic activity in a human cell line.
Only in: Food Scores®
 
some
 
Andrew Axon, Felicity E. B. May, Luke E. Gaughan, Faith M. Williams, Peter G. Blain & Matthew C. Wright. 2012. Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology 298(1-3), 40-51.
Ingestion of tartrazine was associated with behavioral changes in irritability, restlessness, and sleep disturbance in some children.
Only in: Food Scores®
 
some
 
K. S. Rowe & K. J. Rowe. 1994. Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. The Journal of pediatrics 125(5 Pt 1), 691-8.
Eating a mix of artificial colors with sodium benzoate result in increased hyperactivity in 3-year-old and 8/9-year-old children in the general population.
Only in: Food Scores®
 
some
 
Donna McCann, John O. Warner, Edmund Sonuga-Barke, Emily Prince, Lucy Porteous, Kris Lok, Elizabeth Kitchin, Kate Grimshaw, Lindy Dalen, Debbie Crumpler, Alison Cooper, Angelina Barrett & Jim Stevenson. 2007. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet 370(9598), 1560-7.
A peer-reviewed study found that this substance caused neurobehavioral effects in animals at high doses.
Only in: Food Scores®
 
some
 
Kamel, M.M. & El-lethey, H.S. 2011. The Potential Health Hazard of Tartrazine and Levels of Hyperactivity, Anxiety-Like Symptoms, Depression and Anti-social behaviour in Rats. Journal of American Science 7(6), 1211-8.
Review article concluded that chemical caused hypersensitivity reactions.
 
some
 
Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46. - Peer Reviewed Literature
Review article concluded that chemical caused hypersensitivity reactions.
 
some
 
Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46. - Peer Reviewed Literature
A peer-reviewed study found that this substance caused neurobehavioral effects in animals at high doses.
Only in: Food Scores®
 
some
 
Kamel, M.M. & El-lethey, H.S. 2011. The Potential Health Hazard of Tartrazine and Levels of Hyperactivity, Anxiety-Like Symptoms, Depression and Anti-social behaviour in Rats. Journal of American Science 7(6), 1211-8.
A peer-reviewed study found that this substance caused neurobehavioral effects in animals at high doses.
Only in: Food Scores®
 
some
 
Toyohito Tanaka. 2006. Reproductive and neurobehavioural toxicity study of tartrazine administered to mice in the diet. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 44(2), 179-87.
A peer-reviewed study found that this substance caused neurobehavioral effects in animals at high doses.
Only in: Food Scores®
 
some
 
Toyohito Tanaka, Osamu Takahashi, Shinshi Oishi & Akio Ogata. 2008. Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice. Reproductive toxicology (Elmsford, N.Y.) 26(2), 156-63.
Allergic reactions have been reported in humans.
 
some
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 23. SCCNFP/0786/04.
Allergic reactions have been reported in humans.
 
some
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 23. SCCNFP/0786/04.
NTP Toxcast scored 1.5-2.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
NTP Toxcast scored 1.5-2.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Developmental neurotoxicity observed in chicken embryos.
 
some
 
Aysegul Ozdemir Ovalioglu, Talat Cem Ovalioglu, Gokhan Canaz, Aysegul Esen Aydin, Sema Arslan, Mehmet Sar & Erhan Emel. 2020. Effects of Tartrazine on Neural Tube Development in the Early Stage of Chicken Embryos. Turkish neurosurgery 30(4), 583-587.
No genotoxicity observed in an in vivo assay.
 
low
 
Maria Bastaki, Thomas Farrell, Sachin Bhusari, Kamala Pant & Rohan Kulkarni. 2017. Lack of genotoxicity in vivo for food color additive Tartrazine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 105, 278-284.
No reproductive or developmental effects observed in animal tests.
 
low
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 23. SCCNFP/0786/04.
No reproductive or developmental effects observed in animal tests.
 
low
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 23. SCCNFP/0786/04.

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: BIPHENYL-2-YLAMINE
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of causing genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
May cause cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Causes damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Very toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Fatal if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of damaging fertility.
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of damaging the unborn child.
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Carcinogenic to humans
 
some
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: CADMIUM
Known To Be Human Carcinogen
 
some
 
NTP 14th Report on Carcinogens - National Toxicology Program (NTP)
Impurity: CADMIUM
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: CADMIUM
kidney damage
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: CADMIUM
suspected human carcinogen
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: BIPHENYL-2-YLAMINE
Harmful if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: BIPHENYL-2-YLAMINE
Harmful to aquatic life with long lasting effects
 
low
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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