developmentb
D

CI 42090 (FD&C BLUE NO. 1 OR D&C BLUE NO. 4)

 
This substance ranges from C to D depending on concentration/usage.
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
Low Concern
 
Cancer
 
Low Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of nervous system effects; skin irritation/allergies/damage; kidney and urinary effects
CI 42090 (FD&C Blue No. 1 or D&C Blue No. 4) can be found in 86 products.
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Evidence

Health issue
 
Level of Concern
 
Source
A review study found that cell-based screening tests suggest the potential for neurotoxicity.
 
some
 
Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46. - Peer Reviewed Literature
A review study found that cell-based screening tests suggest the potential for neurotoxicity.
 
some
 
Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46. - Peer Reviewed Literature
NTP Toxcast scored 2.5-3.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
The European Commission's Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers reports this substance can irritate the skin.
 
some
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
NTP Toxcast scored 2.5-3.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
The European Commission's Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers reports this substance can irritate the skin.
 
some
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Neurobehavioral effects observed in animal study.
 
some
 
Toyohito Tanaka, Osamu Takahashi, Akiko Inomata, Akio Ogata & Dai Nakae. 2012. Reproductive and neurobehavioral effects of brilliant blue FCF in mice. Birth defects research. Part B, Developmental and reproductive toxicology 95(6), 395-409.
Not classifiable as to its carcinogenicity to humans
 
low
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Not classifiable as to its carcinogenicity to humans
 
low
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
acute toxicity, oral LD50 (mg/kg)
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
acute toxicity, oral LD50 (mg/kg)
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
No evidence of reproductive or developmental toxicity in animal testing.
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Little evidence of genotoxicity in animal or in vitro testing.
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Not found to be carcinogenic in animal testing.
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
EFSA panel concluded there is no concern for genotoxicity.
 
low
 
European Food Safety Authority. 2010. Scientific Opinion on the re-evaluation of Brilliant Blue FCF (E 133) as a food additive. EFSA Journal 8(11), 1853.
No evidence of reproductive or developmental toxicity in animal testing.
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Little evidence of genotoxicity in animal or in vitro testing.
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Not found to be carcinogenic in animal testing.
 
low
 
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
EFSA panel concluded there is no concern for genotoxicity.
 
low
 
European Food Safety Authority. 2010. Scientific Opinion on the re-evaluation of Brilliant Blue FCF (E 133) as a food additive. EFSA Journal 8(11), 1853.

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: ANILINE
Suspected of causing genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Causes damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Known to cause cancer
 
some
 
Proposition 65 List (2020 Update) - California OEHHA (Office of Environmental Health Hazard Assessment)
Impurity: CADMIUM
Suspected of causing genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
May cause cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Causes damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Very toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Fatal if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of damaging fertility.
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of damaging the unborn child.
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Carcinogenic to humans
 
some
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: CADMIUM
Known To Be Human Carcinogen
 
some
 
NTP 14th Report on Carcinogens - National Toxicology Program (NTP)
Impurity: ANILINE
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: ANILINE
Probably carcinogenic to humans
 
some
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: CADMIUM
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: ANILINE
Toxic if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
kidney damage
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: CADMIUM
suspected human carcinogen
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ANILINE
suspected of causing genetics defects
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
confirmed animal carcinogen with unknown relevance to humans
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Toxic of swallowed
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
may cause respiratory irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Causes serious eye damage
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Not classifiable as to its carcinogenicity to humans
 
low
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: ANILINE
EPA testing shows this substance has moderate acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
Impurity: ANILINE
EPA testing shows this substance has low acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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