Evidence
Health issue
Level of Concern
Source
The European Commission's Scientific Committee on Consumer Safety reports this substance lacks data on contact allergy in humans.
low
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
No evidence of skin sensitization from human and animal tests.
low
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2018. RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 122 Suppl 1, S738-S746.
No genotoxicity observed in in vitro tests using human or bacterial cells.
low
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2018. RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 122 Suppl 1, S738-S746.
No developmental or reproductive toxicity observed in an animal test.
low
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2018. RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 122 Suppl 1, S738-S746.
