The European Commission's Scientific Committee on Consumer Safety reports this substance lacks data on contact allergy in humans.
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low
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EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
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No evidence of skin sensitization from human and animal tests.
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low
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A. Lapczynski, S. Tsang, Y. Tokura, Y. Thakkar, G. Sullivan, I. G. Sipes, T. W. Schultz, D. Salvito, N. Sadekar, J. Romine, G. Ritacco, T. M. Penning, A. Patel, D. O'Brien, D. C. Liebler, A. M. Api, S. La Cava, K. Joshi, L. Jones, A. D. Fryer, M. Francis, C. Deodhar, W. Dekant, M. Date, M. L. Dagli, J. Buschmann, G. A. Burton, M. Bruze, D. Botelho & D. Belsito. 2018. RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 122 Suppl 1, S738-S746.
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No genotoxicity observed in in vitro tests using human or bacterial cells.
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low
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A. Lapczynski, S. Tsang, Y. Tokura, Y. Thakkar, G. Sullivan, I. G. Sipes, T. W. Schultz, D. Salvito, N. Sadekar, J. Romine, G. Ritacco, T. M. Penning, A. Patel, D. O'Brien, D. C. Liebler, A. M. Api, S. La Cava, K. Joshi, L. Jones, A. D. Fryer, M. Francis, C. Deodhar, W. Dekant, M. Date, M. L. Dagli, J. Buschmann, G. A. Burton, M. Bruze, D. Botelho & D. Belsito. 2018. RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 122 Suppl 1, S738-S746.
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No developmental or reproductive toxicity observed in an animal test.
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low
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A. Lapczynski, S. Tsang, Y. Tokura, Y. Thakkar, G. Sullivan, I. G. Sipes, T. W. Schultz, D. Salvito, N. Sadekar, J. Romine, G. Ritacco, T. M. Penning, A. Patel, D. O'Brien, D. C. Liebler, A. M. Api, S. La Cava, K. Joshi, L. Jones, A. D. Fryer, M. Francis, C. Deodhar, W. Dekant, M. Date, M. L. Dagli, J. Buschmann, G. A. Burton, M. Bruze, D. Botelho & D. Belsito. 2018. RIFM fragrance ingredient safety assessment, ethyl 2-methylbutyrate, CAS Registry Number 7452-79-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 122 Suppl 1, S738-S746.
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