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HOME / INGREDIENTS / Fd&c yellow no. 6 (ci 15985)


D

FD&C Yellow No. 6 (CI 15985)

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COMMONLY FOUND IN


SYNONYMS

USACERT FD&C YELLOW NO. 6, SUN ORANGE A GEIGY, ORANGE YELLOW S, USACERT YELLOW NO. 6, SUN YELLOW FCF, SUN YELLOW EXTRA PURE A, YELLOW NO. 6, SUN YELLOW EXTRA CONC. A EXPORT, VITASYN ORANGE, FD&C YELLOW NO. 6 (CI 15985)


RESTRICTED

EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

  • No Data
    Asthma / Respiratory
  • No Data
    Skin Allergies & Irritation
  • SOME
    Developmental & Reproductive Toxicity
  • No Data
    Cancer
  • No Data
    Environment


Top Scoring Factors

Evidence of general systemic/organ effects; developmental/endocrine/reproductive effects; damage to DNA


Ingredient concerns

  • CONCERNS
Health Issue Level of Concern Source
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Synthetic food dyes are associated with adverse neurobehavioral outcomes in children.

Only in: Food Scores®

high

2021. Potential Neurobehavioral Effects of Synthetic Food Dyes in Children. California Environmental Protection Agency. Office of Environmental Health Hazard Assessment.

The European Food Safety Authority concluded that this substance had the potential to impact testicular health.

some

European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive. EFSA Journal 7(11), 1330.

EFSA concludes there is limited evidence that Yellow 6 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population"

some

European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive. EFSA Journal 7(11), 1330.

Suspected of causing genetic defects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

May cause cancer

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Causes damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Fatal if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of damaging fertility.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of damaging the unborn child.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Known To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

Probably carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

A review article reports mixed evidence of genotoxicity.

some

Peer Reviewed Literature: Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22.

A review article reports evidence of impacts on male gonads in rats.

some

Peer Reviewed Literature: Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22.

A peer-reviewed study reports this substance shows estrogenic activity in a human cell line.

Only in: Food Scores®

some

Andrew Axon, Felicity E. B. May, Luke E. Gaughan, Faith M. Williams, Peter G. Blain & Matthew C. Wright. 2012. Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology 298(1-3), 40-51.

A review article reports mixed evidence of genotoxicity.

some

Peer Reviewed Literature: Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22.

A review article reports evidence of impacts on male gonads in rats.

some

Peer Reviewed Literature: Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22.

A peer-reviewed study reports this substance shows estrogenic activity in a human cell line.

Only in: Food Scores®

some

Andrew Axon, Felicity E. B. May, Luke E. Gaughan, Faith M. Williams, Peter G. Blain & Matthew C. Wright. 2012. Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology 298(1-3), 40-51.

kidney damage

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

EFSA concludes that some sensitive individuals may experience allergic reactions at dose levels within the ADI.

some

European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive. EFSA Journal 7(11), 1330.

suspected human carcinogen

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

Review article concluded that chemical caused hypersensitivity reactions.

some

Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.

Review article concluded that chemical caused hypersensitivity reactions.

some

Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.

Reduced pup bodyweight at 750 mg/kg-day and higher.

Only in: Food Scores®

some

Joint FAO/WHO Expert Committee on Food Additives (JECFA). 2012. Safety evaluation of certain food additives and contaminants, WHO Food Additives Series: 65. World Health Organ Tech Rep Ser.

NTP Toxcast scored 1.5-2.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

NTP Toxcast scored 1.5-2.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

No evidence of genotoxicity.

low

Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.

No evidence of genotoxicity.

low

Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.



Understanding scores

EWG provides information on cleaning product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.

HOW WE DETERMINE SCORES

Hazard score

The Healthy Cleaning ingredient hazard score, from A to F, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend


3

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