In vivo and in vitro testing found no evidence of genotoxicity.
|
some
|
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
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NTP Toxcast scored 2.5-3.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
Categorised as possible contact allergen.
|
some
|
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
|
Impacts on liver enzyme function observed in rats.
|
some
|
Hye Gwang Jeong, Young-Jin Chun, Chul-Ho Yun, Chang-Kiu Moon, Hye-Sook Lee, Sang Seop Han, Eung-Seok Lee & Tae Cheon Jeong. 2002. Induction of cytochrome P450 1A and 2B by alpha- and beta-ionone in Sprague Dawley rats. Archives of pharmacal research 25(2), 197-201.
|
Human and animal testing found no evidence of skin sensitization.
|
low
|
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
|
Animal testing shows no evidence of developmental or reproductive toxicity.
|
low
|
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
|
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
|
low
|
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
|