Evidence
Health issue
Level of Concern
Source
The international Organisation for Economoic Co-operation and Development reported that the acute dermal LD50 for the hydrotrope calcium xylene sulfonate is greater than 624 mg/kg.
moderate
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
suspected of causing cancer
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
suspected of causing genetics defects
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The international Organisation for Economoic Co-operation and Development reported that the lowest acute oral LD50 for the hydrotrope calcium xylene sulfonate is 1044 mg/kg.
some
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
Toxic of swallowed
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Harmful in contact with skin
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
harmful in inhaled
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not skin irritants.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not skin sensitizers.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
This chemical has been verified to be of low concern in cleaning products based on experimental and modeled data as assessed by the EPA.
low
Environmental Protection Agency (EPA): Safer Chemical Ingredients List (2018-02-28)
The international Organisation for Economoic Co-operation and Development reported that the acute inhalation LC50 for the hydrotrope sodium toluene sulfonate is greater than 557 mg/L.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not genotoxic.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not carcinogenic via dermal exposure.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that the hydrotrope calcium xylene sulfonate is not teratogenic.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not toxic to reproduction.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are readily biodegradable under aerobic conditions.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that the lowest acute aquatic LC50 for hydrotropes is 230 mg/L.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
