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D

QUATERNARY AMMONIUM COMPOUNDS, BENZYL-C10-16-ALKYLDIMETHYL, CHLORIDES

 

Unacceptable: EWG VERIFIED products cannot contain this ingredient.

This substance ranges from C to D depending on concentration/usage.

Asthma/Respiratory
 
Moderate Concern
 
Skin Allergies &
Irritation
 
No Data, Some Concern
 
Developmental &
Reproductive Toxicity
 
Some Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of respiratory effects; developmental/endocrine/reproductive effects
Quaternary ammonium compounds, benzyl-C10-16-alkyldimethyl, chlorides can be found in 0 products.
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Evidence

Health issue
 
Level of Concern
 
Source
Asthmagen (sensitizing)
 
moderate
 
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Asthmagen (sensitizing)
 
moderate
 
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
 
some
 
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea & Terry C. Hrubec. 2015. Quaternary Ammonium Disinfectants Cause Subfertility in Mice by Targeting both Male and Female Reproductive Processes. Reproductive toxicology (Elmsford, N.Y.).
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
 
some
 
Vanessa E. Melin, Haritha Potineni, Patricia Hunt, Jodi Griswold, Bill Siems, Stephen R. Werre & Terry C. Hrubec. 2014. Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive toxicology (Elmsford, N.Y.) 50, 163-70.
Quaternary ammonium compounds detected in human blood was associated with increased inflammation, decreased mitochondrial function and disruption of cholesterol.
 
some
 
Terry C. Hrubec, Ryan P. Seguin, Libin Xu, Gino A. Cortopassi, Sandipan Datta, Alexandra L. Hanlon, Alicia J. Lozano, Valerie A. McDonald, Claire A. Healy, Tyler C. Anderson, Najaha A. Musse & Richard T. Williams. 2021. Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure. Toxicology reports 8, 646-656.
This substance impacted cholesterol biosynthesis.
 
some
 
Josi Herron, Rosalyn C. Reese, Keri A. Tallman, Rohini Narayanaswamy, Ned A. Porter & Libin Xu. 2016. Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicological sciences : an official journal of the Society of Toxicology 151(2), 261-70.
Quaternary ammonium compounds altered neurodevelopment in cells.
 
some
 
Josi M. Herron, Hideaki Tomita, Collin C. White, Terrance J. Kavanagh & Libin Xu. 2021. Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment. Chemical research in toxicology 34(5), 1265-1274.
 
 
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EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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