Health issue
Level of Concern
Source
Component: METHYLCHLOROISOTHIAZOLINONE
The US EPA reports the LC50 value is very toxic to aquatic life.
high
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLISOTHIAZOLINONE
The US EPA reports the LC50 value is very toxic to aquatic life.
high
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
Component: METHYLISOTHIAZOLINONE
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
Component: METHYLCHLOROISOTHIAZOLINONE
The US EPA reports this substance is a skin sensitizer.
some
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLISOTHIAZOLINONE
The US EPA reports this substance is a skin sensitizer.
some
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLCHLOROISOTHIAZOLINONE
The peer-reviewed study reports methylchloroisothiazolinone is mutagenic
some
T. H. Connor, P. G. Tee, M. Afshar & K. M. Connor. 1996. Mutagenicity of cosmetic products containing Kathon. Environmental and molecular mutagenesis 28(2), 127-32.
Component: METHYLCHLOROISOTHIAZOLINONE
NIOSH reports that this substance is a skin sensitizer.
some
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
Component: METHYLCHLOROISOTHIAZOLINONE
The US EPA reports this substance causes skin irritation.
some
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLISOTHIAZOLINONE
NIOSH reports that this substance is a skin sensitizer.
some
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
Component: METHYLISOTHIAZOLINONE
The US EPA reports this substance causes skin irritation.
some
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLISOTHIAZOLINONE
A Cosmetic Ingredient Review Expert Panel found that methylchloroisothiazinolinone causes allergic contact dermatitis.
some
Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. 2010. Final report of the safety assessment of methylisothiazolinone. International journal of toxicology 29(4 Suppl), 187S-213S.
Component: METHYLISOTHIAZOLINONE
A Cosmetic Ingredient Review Expert Panel found that methylchloroisothiazinolinone is a skin sensitizer.
some
Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. 2010. Final report of the safety assessment of methylisothiazolinone. International journal of toxicology 29(4 Suppl), 187S-213S.
Component: METHYLCHLOROISOTHIAZOLINONE
A review article reports that this substance causes contact allergies.
some
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
Component: METHYLCHLOROISOTHIAZOLINONE
A review article reports that this substance is a skin sensitizer.
some
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
Component: METHYLCHLOROISOTHIAZOLINONE
NIOSH reports that this substance is a skin irritant.
some
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
Component: METHYLISOTHIAZOLINONE
A review article reports that this substance causes contact allergies.
some
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
Component: METHYLISOTHIAZOLINONE
A review article reports that this substance is a skin sensitizer.
some
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
Component: METHYLISOTHIAZOLINONE
NIOSH reports that this substance is a skin irritant.
some
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
Component: METHYLCHLOROISOTHIAZOLINONE
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Component: METHYLCHLOROISOTHIAZOLINONE
A peer-reviewed study reports that this substance causes allergic contact dermatitis.
some
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
Component: METHYLCHLOROISOTHIAZOLINONE
A peer-reviewed study reports that this substance is a skin sensitizer.
some
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
Component: METHYLCHLOROISOTHIAZOLINONE
A peer-reviewed study reports that this substance is a skin sensitizer.
some
D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.
Component: METHYLCHLOROISOTHIAZOLINONE
A peer-reviewed study reports this substance causes dermatitis.
some
Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.
Component: METHYLISOTHIAZOLINONE
A peer-reviewed study reports this substance causes dermatitis.
some
Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.
Component: METHYLISOTHIAZOLINONE
A peer-reviewed study reports that this substance causes allergic contact dermatitis.
some
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
Component: METHYLISOTHIAZOLINONE
A peer-reviewed study reports that this substance is a skin sensitizer.
some
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
Component: METHYLISOTHIAZOLINONE
A peer-reviewed study reports that this substance is a skin sensitizer.
some
D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.
Component: METHYLCHLOROISOTHIAZOLINONE
The US EPA reports it is unknown if this substance is carcinogenic.
low
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLISOTHIAZOLINONE
The US EPA reports it is unknown if this substance is carcinogenic.
low
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The European Union Ecolabel program reports this substance in inherently biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
Component: METHYLISOTHIAZOLINONE
The European Union Ecolabel program reports this substance in inherently biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
Component: METHYLCHLOROISOTHIAZOLINONE
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.
low
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Component: METHYLISOTHIAZOLINONE
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.
low
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.