Isothiazolinones
The US EPA reports the LC50 value is very toxic to aquatic life.

high

U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.

Isothiazolinones
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life

some

EU Ecolabel: Detergents Ingredients Database

Isothiazolinones
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life

some

EU Ecolabel: Detergents Ingredients Database

Isothiazolinones
The US EPA reports this substance is a skin sensitizer.

some

U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.

Isothiazolinones
The peer-reviewed study reports methylchloroisothiazolinone is mutagenic

some

T. H. Connor, P. G. Tee, M. Afshar & K. M. Connor. 1996. Mutagenicity of cosmetic products containing Kathon. Environmental and molecular mutagenesis 28(2), 127-32.

Isothiazolinones
The US EPA reports this substance causes skin irritation.

some

U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.

Isothiazolinones
NIOSH reports that this substance is a skin sensitizer.

some

Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.

Isothiazolinones
A review article reports that this substance causes contact allergies.

some

M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.

Isothiazolinones
A review article reports that this substance is a skin sensitizer.

some

M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.

Isothiazolinones
NIOSH reports that this substance is a skin irritant.

some

Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.

Isothiazolinones
A peer-reviewed study reports that this substance causes allergic contact dermatitis.

some

Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.

Isothiazolinones
A peer-reviewed study reports that this substance is a skin sensitizer.

some

Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.

Isothiazolinones
A peer-reviewed study reports that this substance is a skin sensitizer.

some

D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.

Isothiazolinones
A peer-reviewed study reports this substance causes dermatitis.

some

Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.

Isothiazolinones
The US EPA reports it is unknown if this substance is carcinogenic.

low

U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.

Isothiazolinones
The European Union Ecolabel program reports this substance in inherently biodegradable.

low

EU Ecolabel: Detergents Ingredients Database

Isothiazolinones
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.

low

U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.