Evidence
Health issue
Level of Concern
Source
Conditioning Agents
A structurally similar compound is know to be an asthmagen (sensitizing).
A structurally similar compound is know to be an asthmagen (sensitizing).
moderate
2020. Environmental Working Group. 2020. Quaternary ammonium compounds structural similarities.
Conditioning Agents
Fatal in contact with skin
Only in: Household Cleaners
Fatal in contact with skin
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Conditioning Agents
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Conditioning Agents
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
some
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea & Terry C. Hrubec. 2015. Quaternary Ammonium Disinfectants Cause Subfertility in Mice by Targeting both Male and Female Reproductive Processes. Reproductive toxicology (Elmsford, N.Y.).
Conditioning Agents
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
some
Vanessa E. Melin, Haritha Potineni, Patricia Hunt, Jodi Griswold, Bill Siems, Stephen R. Werre & Terry C. Hrubec. 2014. Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive toxicology (Elmsford, N.Y.) 50, 163-70.
Conditioning Agents
Toxic of swallowed
Only in: Household Cleaners
Toxic of swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Conditioning Agents
Quaternary ammonium compounds detected in human blood was associated with increased inflammation, decreased mitochondrial function and disruption of cholesterol.
Quaternary ammonium compounds detected in human blood was associated with increased inflammation, decreased mitochondrial function and disruption of cholesterol.
some
Terry C. Hrubec, Ryan P. Seguin, Libin Xu, Gino A. Cortopassi, Sandipan Datta, Alexandra L. Hanlon, Alicia J. Lozano, Valerie A. McDonald, Claire A. Healy, Tyler C. Anderson, Najaha A. Musse & Richard T. Williams. 2021. Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure. Toxicology reports 8, 646-656.
Conditioning Agents
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Conditioning Agents
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Conditioning Agents
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Conditioning Agents
This substance impacted cholesterol biosynthesis.
This substance impacted cholesterol biosynthesis.
some
Josi Herron, Rosalyn C. Reese, Keri A. Tallman, Rohini Narayanaswamy, Ned A. Porter & Libin Xu. 2016. Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicological sciences : an official journal of the Society of Toxicology 151(2), 261-70.
Conditioning Agents
Quaternary ammonium compounds altered neurodevelopment in cells.
Quaternary ammonium compounds altered neurodevelopment in cells.
some
Josi M. Herron, Hideaki Tomita, Collin C. White, Terrance J. Kavanagh & Libin Xu. 2021. Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment. Chemical research in toxicology 34(5), 1265-1274.
