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HOME / INGREDIENTS / Acid yellow 73 (uncertified d&c yellow no. 7 or 8)


D

Acid Yellow 73 (Uncertified D&C Yellow No. 7 or 8)

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COMMONLY FOUND IN


SYNONYMS

ACID YELLOW 73 SODIUM SALT (UNCERTIFIED D&C YELLOW NO. 7 OR D&C YELLOW NO. 8), ACID YELLOW 73, ACID YELLOW 73 SODIUM SALT, C.I. ACID YELLOW 73, ACID YELLOW 73 (UNCERTIFIED D&C YELLOW NO. 7 OR 8)


RESTRICTED

EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

  • No Data
    Asthma / Respiratory
  • No Data
    Skin Allergies & Irritation
  • SOME
    Developmental & Reproductive Toxicity
  • No Data
    Cancer
  • No Data
    Environment


Top Scoring Factors

Evidence of developmental/endocrine/reproductive effects; damage to DNA; damage to vision


Ingredient concerns

  • CONCERNS
Health Issue Level of Concern Source
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Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

May damage the unborn child.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

A review article concludes this substance may be a develomental toxin based on evidence in humans and animals.

some

Raphael Alford, Haley M. Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi & Peter L. Choyke. 2009. Toxicity of organic fluorophores used in molecular imaging: literature review. Molecular imaging 8(6), 341-54.

Toxic if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

peripheral nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

kidney damage

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

central nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

Harmful if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

NTP Toxcast scored 2.5-3.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

A study by the National Toxicology Program reports this substance was genotoxic in vitro.

some

B. C. Myhr & W. J. Caspary. 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environmental and molecular mutagenesis 18(1), 51-83.

may cause cancer

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause cancer

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Clear evidence of endocrine disruption in at least one animal study

some

EU Endocrine: EU Endocrine Disrupters

Known to cause reproductive toxicity (to females)

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Known to cause reproductive toxicity (to males)

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Known to cause reproductive toxicity

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

May damage the unborn child.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of damaging fertility.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

Known To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

The Agency for Toxic Substances and Disease Registry reports this substance damages the cardiovascular system.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

The Agency for Toxic Substances and Disease Registry reports this substance damages the immune system.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

The Agency for Toxic Substances and Disease Registry reports this substance causes damage to the skin.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

The Agency for Toxic Substances and Disease Registry reports this substance can damage the kidneys.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

Causes damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Fatal if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Probably carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

Reasonably Anticipated To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

A review article reports that adverse reactions to this substance have been reported in humans.

some

Ilyse S. Kornblau & Jaafar F. El-Annan. 1900. Adverse reactions to fluorescein angiography: A comprehensive review of the literature. Survey of ophthalmology 64(5), 679-693.

Toxic if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

peripheral nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

hematologic effects

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

confirmed human carcinogen

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

cancer

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

lung cancer

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

kidney damage

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

central nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

EPA's review of industry submitted toxicity data and the potential for human exposure concludes that this substance poses a high risk for human health.

some

Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Risks

Harmful if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

harmful in inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Harmful if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Possibly carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

May cause damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Harmful if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

The Agency for Toxic Substances and Disease Registry reports this substance shows some evidence of damage to the developing fetus.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

A peer-reviewed article reports that people with a history of drug allergy may have adverse reactions to this substance.

some

Zhaoan Su, Panpan Ye, Yan Teng, Lixia Zhang & Xiaohong Shu. 2012. Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4), 410-3.

A peer-reviewed article reports that allergic reactions to this substance are observed in humans.

some

Dimitrios C. Kalogeromitros, Michael P. Makris, Xenophon S. Aggelides, Anagnostis I. Mellios, Fani C. Giannoula, Kyriaki A. Sideri, Alexander A. Rouvas & Panagiotis G. Theodossiadis. 2011. Allergy skin testing in predicting adverse reactions to fluorescein: a prospective clinical study. Acta ophthalmologica 89(5), 480-3.

causes damage to organs

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause cancer

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause harm to breast-fed children

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may damage fertility or the unborn child

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes damage to organs through prolonged or repeated exposure

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Fatal if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

fatal if inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

confirmed animal carcinogen with unknown relevance to humans

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes serious eye damage

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

may cause damage to organs

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Harmful if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

harmful in inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause damage to organs through prolonged or repeated exposure

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause drowsiness or dizziness

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

skin irritation

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

May cause an allergic skin reaction

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause respiratory irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes serious eye irritation

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

NTP Toxcast scored 1.5-2.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

Causes serious eye damage

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

not classifiable as a human carcinogen

low

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Not classifiable as to human carcinogenicity

low

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

not classifiable as a human carcinogen

low

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration

Only in: Household Cleaners

low

U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)

Low acute oral toxicty.

low

Raphael Alford, Haley M. Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi & Peter L. Choyke. 2009. Toxicity of organic fluorophores used in molecular imaging: literature review. Molecular imaging 8(6), 341-54.



Understanding scores

EWG provides information on cleaning product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.

HOW WE DETERMINE SCORES

Hazard score

The Healthy Cleaning ingredient hazard score, from A to F, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend


3

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