Found in these people:
Found in these locations:
Bolinas, CA; Berkeley, CA; New Orleans, LA; Sausalito, CA; Pleasantville, NY
Organophosphate (OP) pesticides like malathion cause significant neurotoxicity in laboratory animals and humans, which is not surprising since they were designed to attack the nervous system of insects. Although these pesticides are not as persistent as some environmental chemicals, they are generally more toxic to the young compared to adults. This means that even short-term exposures, such as during pregnancy or childhood, can result in toxicity. Malathion dicarboxylic acid is a metabolite of malathion.
In humans, malathion can cause typical signs of organophosphate poisoning that include nausea, diarrhea, muscle twitching, blurred vision, headache, respiratory distress, lightheadedness, memory impairment, numbness (especially in the extremities), altered nerve conduction, abnormal heart rate and coma or death at high doses (EPA 2001).
Effects of malathion in laboratory animals include: neurotoxicity (decreased motor activity, excessive salivation, paralysis, altered brain weight, nerve degeneration); eye and skin irritation; lesions of the nasal cavity and larynx; respiratory tract (nasal cavity lesions, lung inflammation and edema); hematological changes; liver toxicity (tumors, increased weight and cellular effects) and thyroid toxicity (tumors and hypothyroidism). Other organs affected include the kidney, spleen, testes and the adrenal gland. Malathion has also been shown to cause mononuclear cell leukemia. Developmental and/or reproductive effects include decreased growth and early pregnancy loss (EPA 2000, California Department of Pesticide Regulation 1997, Sinha 1991, Ozmen 1993, Akhtar 1996).
Malathion Dicarboxylic Acid
Organophosphate pesticides were previously marketed for home use and are now used on produce. Known neurotoxins that are particularly toxic to developing fetuses, infants and children.
Malathion Dicarboxylic Acid has been found in 5 of the 9 people tested in EWG/Commonweal studies. It has also been found in 997 of the 2,125 people tested in CDC biomonitoring studies.
Top health concerns for Malathion Dicarboxylic Acid (References)
|health concern or target organ||weight of evidence|
|Brain and nervous system||unknown|
Results for Malathion Dicarboxylic Acid
- geometric mean: 2.03 ppb in urine
- found in 5 of 9 people in the group
|0||ppb in urine||8|
Malathion Dicarboxylic Acid results
Detailed toxicity classifications (References)
|Nervous system toxicity - weight of evidence unknown/unassessed||Kamel, F. and J. A. Hoppin (2004). Association of pesticide exposure with neurologic dysfunction and disease. Environ Health Perspect 112(9): 950-8.|