|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
May cause cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause reproductive toxicity
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Clear evidence of endocrine disruption in at least one animal study
|
some
|
EU Endocrine: EU Endocrine Disrupters
|
|
Carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Reasonably Anticipated To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
May cause damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
may cause cancer
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
May damage the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause cancer
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Known to cause reproductive toxicity
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Clear evidence of endocrine disruption in at least one animal study
|
some
|
EU Endocrine: EU Endocrine Disrupters
|
|
Known To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
May cause cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause reproductive toxicity (to females)
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Known to cause reproductive toxicity (to males)
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Suspected of damaging fertility.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Reasonably Anticipated To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
Probably carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
peripheral nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
hematologic effects
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
harmful in inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
May cause damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Possibly carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Harmful if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may damage fertility or the unborn child
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause cancer
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause harm to breast-fed children
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
confirmed animal carcinogen with unknown relevance to humans
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
|
some
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
harmful in inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
No eye irritation observed in an animal test.
|
low
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
No dermal sensitization observed in an animal test.
|
low
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
Betaine may play a role in decreasing oxidative stress.
|
low
|
Guangfu Zhao, Fang He, Chenlu Wu, Pan Li, Nengzhang Li, Jinping Deng, Guoqiang Zhu, Wenkai Ren & Yuanyi Peng. 2018. Betaine in Inflammation: Mechanistic Aspects and Applications. Frontiers in immunology 9, 1070.
|
|
Low acute oral toxicity.
|
low
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
Betaine was not carcinogenic in a study in rats (104 week, dietary exposure).
|
low
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
No genotoxicity observed in in vitro assays with human or bacterial cells,
|
low
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
|
low
|
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
|
