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DDT
Score:
Data: Robust
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Endocrine disruption (moderate), Persistence and bioaccumulation (high), Non-reproductive organ system toxicity (low), Ecotoxicology (low), and Occupational hazards (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Persistent, bioaccumulative in wildlife and humans | EU PTBs - PRIO database & Secondary PRIO database |
| Persistent, bioaccumulative in wildlife and humans | National Library of Medicine HazMap |
| Persistent, bioaccumulative in wildlife and humans | United Nations Environment Programme/POPs Treaty |
| Persistent, bioaccumulative in wildlife | Great Lakes BTS (Binational Toxics Strategy) PBTs |
| Persistent, bioaccumulative in wildlife | National Library of Medicine HazMap |
| Persistent, bioaccumulative in wildlife | OSPAR PBTs - Substances of Possible Concern |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Occupational hazards
| Concern | Reference |
|---|---|
| Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Cancer
| Concern | Reference |
|---|---|
| Possible human carcinogen | NTP Report on Carcinogens, 11th Edition |
| Possible human carcinogen | EPA (US. Environmental Protection Agency). Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986 guidelines. |
| Possible human carcinogen | Int'l Agency for Research on Cancer (IARC) - Carcinogens |
| Possible human carcinogen | California EPA Proposition 65 |
| Cancer - strong evidence | Proposition 65 List of Carcinogens (July 2004) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html. |
| Limited evidence of carcinogenicity | CPS&Q - Classification & Labelling |
| Limited evidence of carcinogenicity | Amer Conf of Gov't Industrial Hygienists - Carcinogens |
| Limited evidence of carcinogenicity | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 53;1991 |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| Possible human developmental toxicant | California EPA Proposition 65 |
| Human developmental toxicant - strong evidence | Proposition 65 List of Carcinogens (July 2004) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html. |
Endocrine disruption
| Concern | Reference |
|---|---|
| Human endocrine disruptor - strong evidence | European Commission on Endocrine Disruption |
| One or more studies show significant wildlife and the environment disruption | European Commission on Endocrine Disruption |
| Limited evidence of endocrine disruption | BKH/European Commission Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption: - preparation of a candidate list of substances as a basis for priority setting. Final report-November 2000. http://europa.eu.int/comm/environment/docum/01262_en.htm#bkh. Category 1 chemicals from Annex 1: Candidate list of 553 substances. http://europa.eu.int/comm/environment/docum/bkh_annex_01.pdf, Brucker-Davis, F. Effects of Environmental Synthetic Chemicals on Thyroid Function. Thyroid. 8(9): 827-856. 1998., Illinois EPA. Endocrine Disruptors Strategy. 1997. (Table 1: Preliminary List of Chemicals Associated with Endocrine System Effects in Animals and Humans or In Vitro). http://www.nihs.go.jp/hse/environ/illiepatable.htm, Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html, Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. http://www.wileyeurope.com/cda/product/0,,0471191450%7Cdesc%7C3037,00.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation., World Wildlife Fund. Our Stolen Future. Widespread Pollutants with Endocrine-disrupting Effects. http://www.ourstolenfuture.org/Basics/chemlist.htm. The WWF list is derived from references detailed at http://www.ourstolenfuture.org/Sources/chemsources.htm and was originally published in: Colborn, T., F.S. vom Saal, and A.M. Soto. Developmental Effects of Endocrine-Disrupting Chemicals In Wildlife and Humans. Environmental Health Perspectives 101(5): 378-384. 1993. |
| endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | Illinois EPA Chemicals Associated with Endocrine System |
| endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | Soto et al 1994; Lascombe et al. 2000; Kupfer et al. 1980; Rajapakse et al. 2001 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as toxic or harmful | CPS&Q - Classification & Labelling |
| Limited evidence of gastrointestinal or liver toxicity | National Library of Medicine HazMap |
| Limited evidence of gastrointestinal or liver toxicity | Agency for Toxic Substances and Disease Registry Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, Malachowsky, M.J. Health Effects of Toxic Substances. Government Institutes. Rockville, MD 1995., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation. |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | National Library of Medicine HazMap |
Ecotoxicology
| Concern | Reference |
|---|---|
| Wildlife and environmental toxicity | CPS&Q - Classification & Labelling |
| Wildlife and environmental toxicity | EPA Clean Water Act - Priority Pollutants |
| Wildlife and environmental toxicity | Illinois EPA Chemicals Associated with Endocrine System |
Data gaps
| Concern | Reference |
|---|---|
| 11356 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Data Sources
- EU (European Union). 2006. Persistent, bioaccumulative chemicals identified in PRIO database - a tool for risk reduction of chemicals. Secondary PRIO database - a tool for risk reduction of chemicals. Secondary Kemi. Place Published, Kemi-Swedish Chemicals Inspectorate.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- UNEP (United Nations Environment Programme). 2001. Stockholm Convention on Persistent Organic Pollutants (POPs) — POPs Treaty.
- Great Lakes BTS (Binational Toxics Strategy). 1997. Canada-United States Strategy for the Virtual Elimination of Persistent Toxic Substances in the Great Lakes. Appendix I - Level 1 and Level 2 substances.
- OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
- EPA (US. Environmental Protection Agency). Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986 guidelines.
- IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
- California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
- Proposition 65 List of Carcinogens (July 2004) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html.
- ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 53;1991
- EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
- BKH/European Commission Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption: - preparation of a candidate list of substances as a basis for priority setting. Final report-November 2000. http://europa.eu.int/comm/environment/docum/01262_en.htm#bkh. Category 1 chemicals from Annex 1: Candidate list of 553 substances. http://europa.eu.int/comm/environment/docum/bkh_annex_01.pdf, Brucker-Davis, F. Effects of Environmental Synthetic Chemicals on Thyroid Function. Thyroid. 8(9): 827-856. 1998., Illinois EPA. Endocrine Disruptors Strategy. 1997. (Table 1: Preliminary List of Chemicals Associated with Endocrine System Effects in Animals and Humans or In Vitro). http://www.nihs.go.jp/hse/environ/illiepatable.htm, Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html, Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. http://www.wileyeurope.com/cda/product/0,,0471191450%7Cdesc%7C3037,00.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation., World Wildlife Fund. Our Stolen Future. Widespread Pollutants with Endocrine-disrupting Effects. http://www.ourstolenfuture.org/Basics/chemlist.htm. The WWF list is derived from references detailed at http://www.ourstolenfuture.org/Sources/chemsources.htm and was originally published in: Colborn, T., F.S. vom Saal, and A.M. Soto. Developmental Effects of Endocrine-Disrupting Chemicals In Wildlife and Humans. Environmental Health Perspectives 101(5): 378-384. 1993.
- Illinois EPA (Illinois Environmental Protection Agency). 2000. Preliminary list of chemicals associated with endocrine system effects in animals and humans (*) or in vitro (+). In EPA (U.S. Environmental Protection Agency) 2000. Handbook for Non-Cancer Health Effects Valuation, Appendix C.
- Soto et al 1994; Lascombe et al. 2000; Kupfer et al. 1980; Rajapakse et al. 2001
- Agency for Toxic Substances and Disease Registry Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, Malachowsky, M.J. Health Effects of Toxic Substances. Government Institutes. Rockville, MD 1995., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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