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GLYCYRRHIZA GLABRA ROOT POWDER
Score:
Data: None
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Neurotoxicity (low), Endocrine disruption (moderate), and Non-reproductive organ system toxicity (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| foundation | 8 products |
| concealer | 4 products |
| mask | 1 products |
Endocrine disruption
| Concern | Reference |
|---|---|
| Licorice and its derivative substances disrupt function of the adrenal (corticosteroid hormone) axis. | Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650. |
| Anti-androgenic effects of licorice have been observed in humans. | Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502. |
| Licorice extract exhibits estrogenic activity in vitro. | D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45. |
| Licorice extracts impacted pituitary hormone secretion in vitro and in vivo in rats. | Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85. |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| Licorice consumption during pregnancy is linked to adverse birth outcomes. | Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650. |
| Licorice extract affected male reprodutive function in rats. | Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650. |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Licorice and its constituents/derivatives affect the cardiovascular system by disrupting hormones involved in water/salt balance. | Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10). |
| Effects on liver enzyme function have been observed in humans and animals. | Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650. |
| Chronic exposure to licorice extract caused liver damage in fish. | Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650. |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Licorice and its constituents/derivatives can impact immune function. | Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339. |
Neurotoxicity
| Concern | Reference |
|---|---|
| Licorice derivatives have exhibited neuroprotective, sedative, and antidepressant effects in various studies, indicating a capacity to elicit nervous system effects. | Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339. |
Data gaps
| Concern | Reference |
|---|---|
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Data Sources
- Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
- Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
- D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
- Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.
- Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
- Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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