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PESTICIDES

Score:

Data: Fair

Cancer

Cancer concern is HIGH

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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Cancer

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Concern Reference
Known human carcinogenProposition 65 List of Carcinogens (2013) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html.
Cancer - strong evidenceNAS (National Academy of Sciences) 1993. Pesticides in the Diets of Infants and Children. National Academy of Sciences, Commission of Life Science. Washington, DC. http://www.nap.edu/catalog.php?record_id=2126

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsFederal Food, Drug, and Cosmetic Act (FD&C Act), FIFRA & Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
Recommendation to minimize use in cosmetics - anyCIR (Cosmetic Ingredient Review) 2007. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.

Allergies/immunotoxicity

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Concern Reference
Human Immune System toxicant or allergen - strong evidenceNAS (National Academy of Sciences) 1993. Pesticides in the Diets of Infants and Children. National Academy of Sciences, Commission of Life Science. Washington, DC. http://www.nap.edu/catalog.php?record_id=2126

Neurotoxicity

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Concern Reference
Strong evidence of human neurotoxicityNAS (National Academy of Sciences) 1993. Pesticides in the Diets of Infants and Children. National Academy of Sciences, Commission of Life Science. Washington, DC. http://www.nap.edu/catalog.php?record_id=2126
One or more human case studies show significant any effectsRauh V, Arunajadai S, Horton M, Perera F, Hoepner L, Barr DB, et al 2011. 7-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide. Environ Health Perspect doi: 10.1289/ehp.1003160.

Developmental/reproductive toxicity

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Concern Reference
One or more animal studies show developmental effects at very low dosesBlystone, Chad R, et al. "Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production." Toxicology letters 174.1 (2007): 74-81.

Data gaps

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Concern Reference
25628 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Proposition 65 List of Carcinogens (2013) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html.
  • NAS (National Academy of Sciences) 1993. Pesticides in the Diets of Infants and Children. National Academy of Sciences, Commission of Life Science. Washington, DC. http://www.nap.edu/catalog.php?record_id=2126
  • Federal Food, Drug, and Cosmetic Act (FD&C Act), FIFRA & Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
  • CIR (Cosmetic Ingredient Review) 2007. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Rauh V, Arunajadai S, Horton M, Perera F, Hoepner L, Barr DB, et al 2011. 7-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide. Environ Health Perspect doi: 10.1289/ehp.1003160.
  • Blystone, Chad R, et al. "Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production." Toxicology letters 174.1 (2007): 74-81.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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