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NITROSAMINES

Score:

Data: Fair

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Cancer

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Concern Reference
Possible human carcinogenEPA (US. Environmental Protection Agency). Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986 guidelines.
Possible human carcinogenWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 17, Suppl. 7; ;1987
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Cancer - strong evidenceProposition 65 List of Carcinogens (July 2004) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html.

Developmental/reproductive toxicity

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Concern Reference
Limited evidence of reproductive toxicityUS EPA Roadmaps to Sources of Information on Chemicals Listed in the Emergency Planning Community and Community Right-to-Know Act (Also Known as SARA Title 3), Section 313 Toxic Release Inventory (for Microcomputers). (Report Number EPADFDK92040). 1991. Data file distributed in 2 diskettes by Office of Pollution, Prevention, and Toxics, Environmental Protection Agency, Washington, DC. NOTE: Datasource no longer being maintained by EPA; not currently available online.

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of gastrointestinal or liver toxicityNational Library of Medicine HazMap
Limited evidence of sense organ toxicityLock, EA., and E. Harpur. Toxicology of Sensory System: A Perspective. Human and Experimental Toxicology. 11(6): 442-448. 1992. (Table 1: Chemicals that induce olfactory lesions in experimental animals by either inhalation and/or non-inhalation routes).
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Data gaps

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Concern Reference
12434 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • EPA (US. Environmental Protection Agency). Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986 guidelines.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 17, Suppl. 7; ;1987
  • NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
  • Proposition 65 List of Carcinogens (July 2004) can be obtained from http://wwwoehha.ca.gov/prop65/prop65_list/Newlist.html.
  • US EPA Roadmaps to Sources of Information on Chemicals Listed in the Emergency Planning Community and Community Right-to-Know Act (Also Known as SARA Title 3), Section 313 Toxic Release Inventory (for Microcomputers). (Report Number EPADFDK92040). 1991. Data file distributed in 2 diskettes by Office of Pollution, Prevention, and Toxics, Environmental Protection Agency, Washington, DC. NOTE: Datasource no longer being maintained by EPA; not currently available online.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • Lock, EA., and E. Harpur. Toxicology of Sensory System: A Perspective. Human and Experimental Toxicology. 11(6): 442-448. 1992. (Table 1: Chemicals that induce olfactory lesions in experimental animals by either inhalation and/or non-inhalation routes).
  • EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

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