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CI 15850 (D&C Red No. 6 or 7) Calcium Lake

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lip liner19 products
lipstick14 products
blush8 products
nail polish4 products
bronzer/highlighter2 products

Contamination concerns

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Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Color additive provisionally approved for use in cosmeticsUS. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-099; Chemical_Name: D&C Lakes; ;

Cancer

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Concern Reference
Studies assessing carcinogenicity of this substance have been inadequate.Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.

Irritation (skin, eyes, or lungs)

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Concern Reference
Caused mild skin irritation in animal tests.Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.

Allergies/immunotoxicity

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Concern Reference
May cause or exacerbate dermatitis.Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47.

Data gaps

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Concern Reference
Considered safe based on assumption of low absorptionScientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
The European SCCS recommends that the safety of Pigment Red 57 should be assessed for hair dyes and other uses.Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05891; Chemical_Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, disodium salt; ; CAS: 5858-81-1

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

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Concern Reference
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05891; Chemical_Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, disodium salt; ; CAS: 5858-81-1
Deemed a low human health priority and was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05724; Chemical_Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1); ; CAS: 5281-04-9

Persistence and bioaccumulation

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Concern Reference
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05891; Chemical_Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, disodium salt; ; CAS: 5858-81-1

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-099; Chemical_Name: D&C Lakes; ;
  • Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
  • Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05891; Chemical_Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, disodium salt; ; CAS: 5858-81-1
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05724; Chemical_Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-, calcium salt (1:1); ; CAS: 5281-04-9

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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