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CI 45350 (D&C Yellow No. 7 or 8)

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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lipstick13 products
bath oil/salts/soak5 products
bar soap4 products
depilatory3 products
nail polish3 products
hair color and bleaching2 products
body wash/cleanser1 products
facial moisturizer/treatment1 products
serums & essences1 products
mask1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use onlyFDA Color Additive Status

Allergies/immunotoxicity

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Concern Reference
A peer-reviewed article reports that people with a history of drug allergy may hav adverse reactions to this substance.Zhaoan Su, Panpan Ye, Yan Teng, Lixia Zhang & Xiaohong Shu 2012. Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4), 410-3.

Developmental/reproductive toxicity

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Concern Reference
A review article concludes this substance may be a develomental toxin based on evidence in humans and animals.Raphael Alford, Haley M Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi & Peter L. Choyke. 2009. Toxicity of organic fluorophores used in molecular imaging: literature review. Molecular imaging 8(6), 341-54.

Irritation (skin, eyes, or lungs)

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Concern Reference
Causes serious eye irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; 3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one; -; 2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; 3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one; 3',6'-dihydroxy-3H-spiro[2; cas_numbers: 2321-07-5

Cancer

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Concern Reference
A study by the National Toxicology Program reports this substance was genotoxic in vitro.B C. Myhr & W. J. Caspary. 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environmental and molecular mutagenesis 18(1), 51-83.

Endocrine disruption

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Concern Reference
Evidence of endocrine activity from cellular assays and models.National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 2321-07-5; Chemical_Name: Fluorescein

Data gaps

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Concern Reference
4356 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics: external use onlyFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • Zhaoan Su, Panpan Ye, Yan Teng, Lixia Zhang & Xiaohong Shu 2012. Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4), 410-3.
  • Raphael Alford, Haley M Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi & Peter L. Choyke. 2009. Toxicity of organic fluorophores used in molecular imaging: literature review. Molecular imaging 8(6), 341-54.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; 3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one; -; 2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; 3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one; 3',6'-dihydroxy-3H-spiro[2; cas_numbers: 2321-07-5
  • B C. Myhr & W. J. Caspary. 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environmental and molecular mutagenesis 18(1), 51-83.
  • National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 2321-07-5; Chemical_Name: Fluorescein
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for damaged skin due to increased risk of absorption.
  • This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
  • This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer