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PROPANEDIOL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (low), and Irritation (skin, eyes, or lungs) (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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facial moisturizer/treatment275 products
mask247 products
serums & essences240 products
foundation193 products
concealer131 products
daily use with SPF120 products
facial cleanser91 products
recreational sunscreen90 products
moisturizer87 products
antiperspirant/deodorant71 products
toners/astringents57 products
liquid hand soap57 products
around-eye cream56 products
exfoliant/scrub50 products
conditioner47 products
body wash/cleanser47 products
makeup primer44 products
shampoo42 products
eye shadow42 products
hair treatment/serum34 products
eye liner30 products
hair styling aide29 products
setting powder/spray28 products
makeup remover23 products
mascara20 products
styling gel/lotion18 products
anti-aging17 products
baby sunscreen16 products
bronzer/highlighter15 products
hair color and bleaching15 products
hand sanitizer13 products
antiperspirant/deodorant (men's)12 products
CC cream12 products
lipstick11 products
sunless tanning10 products
9 products
hair spray8 products
detangler8 products
baby shampoo8 products
body firming lotion7 products
shaving cream7 products
BB cream7 products
hand cream6 products
foot moisturizer6 products
after shave6 products
after sun product6 products
shaving cream (men's)6 products
facial powder6 products
mouthwash5 products
baby lotion5 products
blush5 products
brow liner5 products
baby soap4 products
oil controller4 products
fragrance for women3 products
bar soap3 products
lip plumper3 products
eye makeup remover2 products
other eye makeup2 products
bubble bath2 products
damaged skin treatment2 products
lip balm2 products
body spray2 products
toothpaste2 products
beard care2 products
muscle/joint soreness1 products
styling mousse/foam1 products
body oil1 products
glitter1 products
baby bubble bath1 products
baby toothpaste1 products
beard oil1 products
lip balm with SPF1 products
beard cleanser1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancer - alters skin structure, allows other chemicals to penetrate deeper into the skinCosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as skin irritantNational Library of Medicine HazMap
Mild skin irritation observed in animal tests.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;
Causes skin irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Propane-1,3-diol; propane-1,3-diol; -; 1,3-Dihydroxypropane; 1,3-Propanediol; 1,3-Propylene glycol; Propan-1,3-diol; Propane-1,3-diol; Propane-1,3-diol; Susterra; Zemea; cas_numbers: 504-63-2

Cancer

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Concern Reference
Genotoxicity observed in mammalian cell assay.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;

Endocrine disruption

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Concern Reference
Evidence of endocrine disruption in in vitro assays.National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 504-63-2; Chemical_Name: Propanediol

Data gaps

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Concern Reference
81588 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Propane-1,3-diol; propane-1,3-diol; -; 1,3-Dihydroxypropane; 1,3-Propanediol; 1,3-Propylene glycol; Propan-1,3-diol; Propane-1,3-diol; Propane-1,3-diol; Susterra; Zemea; cas_numbers: 504-63-2
  • National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 504-63-2; Chemical_Name: Propanediol
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.

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