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PROPANEDIOL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (low), and Irritation (skin, eyes, or lungs) (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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facial moisturizer/treatment170 products
mask162 products
serums & essences151 products
moisturizer with SPF98 products
foundation96 products
beach & sport sunscreen88 products
facial cleanser51 products
antiperspirant/deodorant47 products
concealer44 products
moisturizer38 products
shampoo36 products
body wash/cleanser35 products
conditioner27 products
exfoliant/scrub24 products
around-eye cream24 products
makeup primer23 products
eye shadow23 products
toners/astringents22 products
liquid hand soap21 products
eye liner18 products
mascara17 products
BB cream16 products
hair styling aide15 products
baby sunscreen15 products
hair treatment/serum15 products
hair color and bleaching14 products
makeup remover13 products
CC cream12 products
styling gel/lotion11 products
makeup with SPF10 products
body firming lotion9 products
anti-aging9 products
sunless tanning9 products
blush8 products
facial powder6 products
detangler6 products
lipstick6 products
Facial Sun Care4 products
baby soap4 products
brow liner4 products
antiperspirant/deodorant (men's)4 products
bronzer/highlighter4 products
after sun product3 products
mouthwash3 products
hair spray3 products
baby shampoo3 products
after shave3 products
shaving cream3 products
shaving cream (men's)3 products
toothpaste2 products
baby lotion2 products
oil controller2 products
hand cream2 products
foot moisturizer2 products
bubble bath2 products
lip balm1 products
baby bubble bath1 products
beard oil1 products
hand sanitizer1 products
baby toothpaste1 products
body spray1 products
lip balm with SPF1 products
damaged skin treatment1 products
eye makeup remover1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancer - alters skin structure, allows other chemicals to penetrate deeper into the skinCosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as skin irritantNational Library of Medicine HazMap
Mild skin irritation observed in animal tests.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;
Causes skin irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Propane-1,3-diol; propane-1,3-diol; -; 1,3-Dihydroxypropane; 1,3-Propanediol; 1,3-Propylene glycol; Propan-1,3-diol; Propane-1,3-diol; Propane-1,3-diol; Susterra; Zemea; cas_numbers: 504-63-2

Cancer

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Concern Reference
Genotoxicity observed in mammalian cell assay.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;

Endocrine disruption

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Concern Reference
Evidence of endocrine disruption in in vitro assays.National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 504-63-2; Chemical_Name: Propanediol

Data gaps

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Concern Reference
81588 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: Propanediol; ; ; Classification: QQQ01; PE; M+;
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Propane-1,3-diol; propane-1,3-diol; -; 1,3-Dihydroxypropane; 1,3-Propanediol; 1,3-Propylene glycol; Propan-1,3-diol; Propane-1,3-diol; Propane-1,3-diol; Susterra; Zemea; cas_numbers: 504-63-2
  • National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 504-63-2; Chemical_Name: Propanediol
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.

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