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P-CHLORO-M-CRESOL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (low), Endocrine disruption (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as irritantCPS&Q - Classification & Labelling

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to low dosesCPS&Q - Classification & Labelling

Allergies/immunotoxicity

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Concern Reference
Human skin toxicant or allergen - strong evidenceIJT 25(S1):29-127, 2006 IJT 16(S3):235-68,1997 (Original Report)
Human skin toxicant or allergen - strong evidenceEWG Assessment of Open Scientific Literature
Limited evidence of immune system toxicity or allergiesCPS&Q - Classification & Labelling
Limited evidence of immune system toxicity or allergiesNordic Council of Ministers (Nordic Allergy Project) Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.

Endocrine disruption

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Concern Reference
Human endocrine disruptor - moderate evidenceEuropean Commission on Endocrine Disruption

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of eye toxicityCPS&Q - Classification & Labelling
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as toxic or harmfulCPS&Q - Classification & Labelling

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 25(S1):29-127, 2006 IJT 16(S3):235-68,1997 (Original Report)

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityCPS&Q - Classification & Labelling
Wildlife and environmental toxicityEPA Clean Water Act - Priority Pollutants
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
369 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limitIJT 25(S1):29-127, 2006 IJT 16(S3):235-68,1997 (Original Report)

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • IJT 25(S1):29-127, 2006 IJT 16(S3):235-68,1997 (Original Report)
  • EWG Assessment of Open Scientific Literature
  • Nordic Council of Ministers (Nordic Allergy Project) Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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