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DIETHANOLAMINE

Score:

Data: Robust

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Non-reproductive organ system toxicity (high), Irritation (skin, eyes, or lungs) (high), Occupational hazards (high), and Contamination concerns (high)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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Contamination concerns

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Chemical
NITROSAMINES

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as irritantCPS&Q - Classification & Labelling
Limited evidence of skin irritationNational Library of Medicine HazMap

Organ system toxicity (non-reproductive)

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Concern Reference
Known human respiratory toxicantEPA Hazardous Air Pollutants
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as toxic or harmfulCPS&Q - Classification & Labelling
Limited evidence of respiratory toxicityUS EPA, Air Risk Information Support Center Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to low dosesCPS&Q - Classification & Labelling

Cancer

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Concern Reference
Carcinogen: California Proposition 65California EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
Possible human carcinogenCalifornia EPA Proposition 65
Limited evidence of carcinogenicityInt'l Agency for Research on Cancer (IARC) - Carcinogens
IARC Group 2BWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php
Cancer - limited evidenceNational Toxicology Program Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2001-2002 for Possible Listing in the Report on Carcinogens, Eleventh Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC.http://ntp-server.niehs.nih.gov/NewHomeRoc/11thConsideration.html National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2004-2005 for Possible Listing in the Report on Carcinogens, Twelfth Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/NewHomeRoc/12thConsideration.html
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 77;2000

Allergies/immunotoxicity

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Concern Reference
Human immune and respiratory toxicant or allergen - strong evidenceAssociation of Occupational and Environmental Clinics
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Developmental/reproductive toxicity

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Concern Reference
Maternal exposure to DEA interferes with brain development (hippocampus region), and this could permanently alter memory function in offspring of mothers exposed to this common ingredient of shampoos and soaps.Craciunescu CN, Wu R, Zeisel SH "Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus." FASEB J. 2006 Aug;20(10):1635-40.

Data gaps

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Concern Reference
2147 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • US EPA, Air Risk Information Support Center Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html
  • EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
  • EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • California EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
  • California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
  • IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php
  • National Toxicology Program Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2001-2002 for Possible Listing in the Report on Carcinogens, Eleventh Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC.http://ntp-server.niehs.nih.gov/NewHomeRoc/11thConsideration.html National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2004-2005 for Possible Listing in the Report on Carcinogens, Twelfth Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/NewHomeRoc/12thConsideration.html
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 77;2000
  • AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
  • Craciunescu CN, Wu R, Zeisel SH "Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus." FASEB J. 2006 Aug;20(10):1635-40.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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